EP 1687029 A1 20060809 - NEUTRALIZING HUMAN ANTIBODIES TO ANTHRAX TOXIN GENERATED BY RECALL TECHNOLOGY
Title (en)
NEUTRALIZING HUMAN ANTIBODIES TO ANTHRAX TOXIN GENERATED BY RECALL TECHNOLOGY
Title (de)
NEUTRALISIERENDE MENSCHLICHE ANTIKÖRPER GEGEN ANTHRAX-TOXIN, ERZEUGT DURCH RECALL-TECHNOLOGIE
Title (fr)
NEUTRALISATION D'ANTICORPS HUMAINS PAR RAPPORT A UNE TOXINE D'ANTHRAX GENERES PAR UNE TECHNOLOGIE DE CONCORDANCE
Publication
Application
Priority
US 0336555 W 20031114
Abstract (en)
[origin: WO2005056052A1] A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect, human peripheral blood cells that have pre-exposed to anthrax toxin are used in the SCID mouse model. This method results in high human antibody titers which are primarily of the IgG isotype and which contain antibodies of high specificity and affinity to desired antigens. The antibodies generated by this method can be used therapeutically and prophylactically for preventing or treating mammals exposed to anthrax. Methods for diagnosis and methods to determine anthrax contamination are also described.
IPC 8 full level
C07K 16/12 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); A61P 31/04 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07K 16/1278 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/92 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005056052 A1 20050623; AU 2003304600 A1 20050629; CA 2545714 A1 20050623; CA 2545714 C 20121016; EP 1687029 A1 20060809; EP 1687029 A4 20070530; EP 2570433 A1 20130320; JP 2007525145 A 20070906; JP 4690196 B2 20110601
DOCDB simple family (application)
US 0336555 W 20031114; AU 2003304600 A 20031114; CA 2545714 A 20031114; EP 03816309 A 20031114; EP 12175602 A 20031114; JP 2005511724 A 20031114