EP 1687273 A1 20060809 - PROCESS FOR PREPARATION OF CHIRAL AMLODIPINE SALTS
Title (en)
PROCESS FOR PREPARATION OF CHIRAL AMLODIPINE SALTS
Title (de)
VERFAHREN ZUR HERSTELLUNG CHIRALER AMLODIPINSALZE
Title (fr)
PROCEDE DE PREPARATION DE SELS CHIRAUX D'AMLODIPINE
Publication
Application
Priority
- IN 2004000324 W 20041019
- IN 1440DE2003 A 20031120
Abstract (en)
[origin: WO2005049571A1] A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(-) Amlodipine and R(+) Amlodipine without isolation of the chiral free base wherein the product has optical purity ranging between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using L(+) or D(-) tartaric acid followed by reaction of the separated tartrate salt with an organic acid to obtain the salt corresponding to the acid used in ee ranging from 96-99%.
IPC 8 full level
C07D 211/90 (2006.01); C07B 57/00 (2006.01)
CPC (source: EP KR)
A61K 31/4422 (2013.01 - KR); C07D 211/90 (2013.01 - EP KR); C07B 2200/07 (2013.01 - EP KR)
Citation (search report)
See references of WO 2005049571A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005049571 A1 20050602; BR PI0416648 A2 20090113; CN 1882543 A 20061220; EP 1687273 A1 20060809; KR 20060086432 A 20060731
DOCDB simple family (application)
IN 2004000324 W 20041019; BR PI0416648 A 20041019; CN 200480034375 A 20041019; EP 04791865 A 20041019; KR 20067009616 A 20060517