Global Patent Index - EP 1687286 A1

EP 1687286 A1 20060809 - DEVELOPMENTS IN BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES (2)

Title (en)

DEVELOPMENTS IN BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES (2)

Title (de)

ENTWICKLUNGEN BEI BIOLOGISCH WIRKSAMEN METHYLEN-BLAU-DERIVATEN (2)

Title (fr)

DERIVES AMELIORES (2) DE BLEU DE METHYLENE BIOLOGIQUEMENT ACTIFS

Publication

EP 1687286 A1 20060809 (EN)

Application

EP 04798628 A 20041122

Priority

  • GB 2004004918 W 20041122
  • GB 0327672 A 20031128
  • GB 0329809 A 20031223

Abstract (en)

[origin: WO2005054217A1] A phenothiazinium compound of Formula (I) for use as an antimicrobial agent for the prevention of microbial infections wherein: Rl, R2, R3 and R4 each independently is an optionally substituted linear, branched or cyclic hydrocarbon group;or Rl and R2 or R3 and R4 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring; X<P-> is a counteranion; and P is 1, 2 or 3. The invention also relates to compositions comprising phenothiazinium. compounds, to selected compounds and their use as medicaments, as PDT agents, as photodiagnostic agents, to a conjugate or composite formed between a phenothiazinium. and a polymer; and to a method for sterilising fluids in which the fluid is passed over the conjugate or composite whilst it is illuminated. The compounds are biologically active photosensitisers which are strongly photocytotoxic and have application in the areas of photodynamic therapy (PDT), as well as for the diagnosis and detection of medical conditions and related uses in photochemical internalisation, in the production of cancer vaccines, in the treatment and prevention of microbial infections and in photodisinfection or photosterilisation.

IPC 8 full level

C07D 279/18 (2006.01); A61K 31/5415 (2006.01); C07D 401/04 (2006.01)

CPC (source: EP)

C07D 279/18 (2013.01); C07D 401/04 (2013.01)

Citation (search report)

See references of WO 2005054217A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005054217 A1 20050616; AU 2004295148 A1 20050616; BR PI0416928 A 20070116; CA 2547556 A1 20050616; EP 1687286 A1 20060809; JP 2007512297 A 20070517; KR 20060111536 A 20061027

DOCDB simple family (application)

GB 2004004918 W 20041122; AU 2004295148 A 20041122; BR PI0416928 A 20041122; CA 2547556 A 20041122; EP 04798628 A 20041122; JP 2006540597 A 20041122; KR 20067010376 A 20060526