EP 1689493 A4 20080423 - CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS
Title (en)
CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS
Title (de)
ANTAGONISTEN DES CALCITONIN GENE RELATED PEPTIDREZEPTORS
Title (fr)
ANTAGONISTES DU RECEPTEUR PEPTIDIQUE LIE AU GENE DE LA CALCITONINE
Publication
Application
Priority
US 0338799 W 20031205
Abstract (en)
[origin: WO2005065779A1] The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
IPC 8 full level
C07D 401/14 (2006.01); A61K 31/495 (2006.01); A61K 31/50 (2006.01); A61K 31/517 (2006.01); A61K 31/52 (2006.01); A61K 31/535 (2006.01); A61K 31/54 (2006.01); A61K 31/55 (2006.01); A61P 25/06 (2006.01); C07D 209/08 (2006.01); C07D 213/64 (2006.01); C07D 221/00 (2006.01); C07D 231/56 (2006.01); C07D 239/00 (2006.01); C07D 239/80 (2006.01); C07D 243/10 (2006.01); C07D 249/18 (2006.01); C07D 263/58 (2006.01); C07D 265/00 (2006.01); C07D 285/00 (2006.01); C07D 317/00 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 491/10 (2006.01); C07D 498/10 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 15/12 (2017.12); A61P 17/02 (2017.12); A61P 25/06 (2017.12); A61P 29/00 (2017.12); C07D 209/08 (2013.01); C07D 231/56 (2013.01); C07D 249/18 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 491/10 (2013.01)
Citation (search report)
- [X] EP 1323709 A1 20030702 - TORAY INDUSTRIES [JP]
- [X] WO 0018764 A1 20000406 - MERCK SHARP & DOHME [GB], et al
- [X] US 5869489 A 19990209 - SHAH SHRENIK K [US], et al
- [X] WO 9844922 A1 19981015 - MERCK & CO INC [US], et al
- [X] GB 2311523 A 19971001 - MERCK & CO INC [US]
- [E] WO 2004063171 A1 20040729 - BOEHRINGER INGELHEIM INT [DE], et al
- [E] WO 03104236 A1 20031218 - BRISTOL MYERS SQUIBB CO [US], et al
- [X] YANG L ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITIES OF POTENT PEPTIDOMIMETICS SELECTIVE FOR SOMATOSTATIN RECEPTOR SUBTYPE 2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 95, September 1998 (1998-09-01), pages 10836 - 10841, XP002916393, ISSN: 0027-8424
- See references of WO 2005065779A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated extension state (EPC)
AL LT LV MK
DOCDB simple family (publication)
WO 2005065779 A1 20050721; AR 046788 A1 20051221; AU 2003297694 A1 20050812; BR 0318637 A 20070213; CA 2549330 A1 20050721; CN 100558428 C 20091111; CN 1917921 A 20070221; EP 1689493 A1 20060816; EP 1689493 A4 20080423; IL 176018 A0 20061005; IS 8482 A 20060526; JP 2007524568 A 20070830; NO 20062648 L 20060802; PE 20051036 A1 20051211; RS 20060382 A 20080929; TW 200529835 A 20050916; TW I284534 B 20070801; UA 81563 C2 20080110
DOCDB simple family (application)
US 0338799 W 20031205; AR P040104530 A 20041203; AU 2003297694 A 20031205; BR 0318637 A 20031205; CA 2549330 A 20031205; CN 200380111030 A 20031205; EP 03819270 A 20031205; IL 17601806 A 20060530; IS 8482 A 20060526; JP 2005513137 A 20031205; NO 20062648 A 20060608; PE 2004001196 A 20041206; TW 93137052 A 20041201; UA A200607510 A 20031205; YU P20060382 A 20031205