EP 1689711 A1 20060816 - METHOD FOR PRODUCING N- 1-(S)-CARBALKOXY-3-PHENYLPROPYL -S-ALANYL-2S, 3AR, 7AS-OCTAHYDROINDOL-2-CARBOXYLIC ACID COMPOUNDS
Title (en)
METHOD FOR PRODUCING N- 1-(S)-CARBALKOXY-3-PHENYLPROPYL -S-ALANYL-2S, 3AR, 7AS-OCTAHYDROINDOL-2-CARBOXYLIC ACID COMPOUNDS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON N- 1-(S)-CARBALKOXY-3-PH ENYLPROPYL -S-ALANYL-2S, 3AR, 7AS-OCTAHYDROINDOL-2-CARBONSÄURE;VERBINDUNGEN
Title (fr)
PROCEDE POUR PRODUIRE DES COMPOSES D' ACIDE N- 1-(S)-CARBALCOXY-3-PHENYLPROPYL -S-ALANYL-2S, 3AR, 7AS-OCTAHYDROINDOL-2-CARBOXYLIQUE
Publication
Application
Priority
- CH 2004000688 W 20041115
- CH 20382003 A 20031128
Abstract (en)
[origin: WO2005051909A1] The invention relates to a method for producing optionally substituted {N-[1-(S)-carbalkoxy-3-phenylpropyl]-S-alanyl-2S, 3aR, 7aS-octahydroindol-2-carboxylic acid} and the pharmaceutically acceptable salts thereof. To this end, a racemic mixture of optionally substituted trans-octahydroindol-2-carboxylic acid is reacted with the N-carboxyanhydride of {N-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-L-alanine}, which is optionally substituted on the phenyl ring, in an appropriate inert solvent, and the obtained optionally substituted {N-[1-(S)-carbalkoxy-3-phenylpropyl]-S-alanyl-2S, 3aR, 7aS-octahydroindol-2-carboxylic acid}, preferably trandolapril, is subsequently isolated, as well as polymorphous forms A and B of trandolapril.
IPC 8 full level
C07D 209/42 (2006.01); A61K 31/404 (2006.01); A61P 9/12 (2006.01); C07K 5/06 (2006.01)
CPC (source: EP US)
A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 209/42 (2013.01 - EP US)
Citation (search report)
See references of WO 2005051909A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005051909 A1 20050609; EP 1689711 A1 20060816; JP 2007512260 A 20070517; US 2007135513 A1 20070614
DOCDB simple family (application)
CH 2004000688 W 20041115; EP 04797245 A 20041115; JP 2006540130 A 20041115; US 58063804 A 20041115