EP 1697502 A2 20060906 - METHODS FOR THE IDENTIFICATION AND PREPARATION OF REGULATOR/SUPPRESSOR T LYMPHOCYTES, COMPOSITIONS AND USES THEREOF
Title (en)
METHODS FOR THE IDENTIFICATION AND PREPARATION OF REGULATOR/SUPPRESSOR T LYMPHOCYTES, COMPOSITIONS AND USES THEREOF
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG UND PRÄPARATION VON REGULATOR/SUPPRESSOR-T-LYMPHOZYTEN, ZUSAMMENSETZUNGEN UND VERWENDUNGEN DAVON
Title (fr)
METHODES D'IDENTIFICATION ET DE PREPARATION DE LYMPHOCYTES T REGULATEURS/SUPPRESSEURS, COMPOSITIONS ET UTILISATIONS
Publication
Application
Priority
- FR 2004003374 W 20041223
- FR 0315360 A 20031224
Abstract (en)
[origin: CA2549394A1] The invention relates to the fields of biology, genetics and medicine. The invention describes methods and compositions enabling (1) the identification of suppressor T cells or lymphocytes (Ts) or the precursors thereof (pTs) fo r diagnostic and therapeutical purposes and for carrying out genomic and proteomic studies, i.e. for the identification of new markers and/or therapeutical targets for said cells; (2) the production of of suppressor T cells or lymphocytes (Ts) or the precursors thereof (pTs) and/or the manipulations thereof in vivo or ex vivo for controlling various pathologica l conditions, including diseases associated with abnormal activity of effector and/or regulator lymphocytes. The invention relates to the preparation of sa id compositions based on Ts lymphocytes and pTS and to the use thereof in cell therapies. The compositions or cell populations based on the Ts lymphocytes and pTs obtained according to the invention are particularly suitable for th e treatment of tumours, auto-immune diseases, allergies, graft-versus-host disease, graft versus infection effects (GVI) or graft-versus-leukemia effec ts (GVL), inflammatory diseases, type 1 diabetes, viral, bacterial or parasitic infections, for immune reconstruction or induction of tolerance in the event of transplantation of stem cells, tissue or organs in mammals.
IPC 8 full level
A61K 35/12 (2015.01); A61K 35/13 (2015.01); A61K 35/14 (2015.01); A61K 35/17 (2015.01); A61K 35/76 (2015.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01)
CPC (source: EP US)
A61K 39/4611 (2023.05 - EP); A61K 39/4621 (2023.05 - EP); A61K 39/46433 (2023.05 - EP); A61K 39/46434 (2023.05 - EP); A61K 39/464402 (2023.05 - EP); A61K 39/464499 (2023.05 - EP); A61P 3/10 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 33/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 41/00 (2018.01 - EP); C12N 5/0636 (2013.01 - EP US); A61K 2039/515 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2864546 A1 20050701; CA 2549394 A1 20050714; EP 1697502 A2 20060906; JP 2007521803 A 20070809; US 2007128670 A1 20070607; WO 2005063969 A2 20050714; WO 2005063969 A3 20051013
DOCDB simple family (application)
FR 0315360 A 20031224; CA 2549394 A 20041223; EP 04816487 A 20041223; FR 2004003374 W 20041223; JP 2006546253 A 20041223; US 58472804 A 20041223