EP 1713509 A2 20061025 - METHOD FOR PRODUCING CONJUGATES OF POLYSACCHARIDES AND POLYNUCLEOTIDES
Title (en)
METHOD FOR PRODUCING CONJUGATES OF POLYSACCHARIDES AND POLYNUCLEOTIDES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON KONJUGATEN AUS POLYSACCHARIDEN UND POLYNUKLEOTIDEN
Title (fr)
PROCEDE POUR PRODUIRE DES CONJUGUES CONSTITUES DE POLYSACCHARIDES ET DE POLYNUCLEOTIDES
Publication
Application
Priority
- EP 2005001252 W 20050208
- DE 102004006249 A 20040209
Abstract (en)
[origin: WO2005074993A2] The invention relates to a method for producing a conjugate of a polynucleotide and a polysaccharide, said method comprising the following steps: a) an aldonic acid of the polysaccharide or a derivative thereof is provided; b) the aldonic acid is reacted with an alcohol derivative, preferably a carbonate derivative of an alcohol, to form an aldonic acid ester, preferably an activated aldonic acid ester; and c) the aldonic acid ester is reacted with the polynucleotide, said polynucleotide comprising a functional amino group. The aldonic acid is reacted with the alcohol derivative in step (b) in a dry aprotic polar solvent.
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EP KR US)
A61K 47/61 (2017.07 - EP US); A61P 43/00 (2017.12 - EP); C07H 21/00 (2013.01 - KR)
Citation (search report)
See references of WO 2005074993A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
WO 2005074993 A2 20050818; WO 2005074993 A3 20060420; AU 2005210142 A1 20050818; BR PI0507540 A 20070703; CA 2555467 A1 20050818; CA 2555467 C 20121009; CN 1917905 A 20070221; CN 1917905 B 20120104; EP 1713509 A2 20061025; JP 2007522164 A 20070809; JP 2013056889 A 20130328; JP 5193468 B2 20130508; KR 101189555 B1 20121016; KR 20060132906 A 20061222; US 2009281296 A1 20091112
DOCDB simple family (application)
EP 2005001252 W 20050208; AU 2005210142 A 20050208; BR PI0507540 A 20050208; CA 2555467 A 20050208; CN 200580004457 A 20050208; EP 05715273 A 20050208; JP 2006552525 A 20050208; JP 2012223269 A 20121005; KR 20067016012 A 20050208; US 59778707 A 20070905