EP 1716178 A1 20061102 - LESS IMMUNOGENIC BINDING MOLECULES
Title (en)
LESS IMMUNOGENIC BINDING MOLECULES
Title (de)
WENIGER IMMUNOGENE BINDUNGSMOLEKÜLE
Title (fr)
MOLECULES DE LIAISON MOINS IMMUNOGENES
Publication
Application
Priority
- EP 2005001573 W 20050216
- EP 04003445 A 20040216
- EP 05715354 A 20050216
Abstract (en)
[origin: WO2005077982A1] The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains whereby one of said at least two domains specifically binds to/interacts with the human CD3 complex and said domain comprises an amino acid sequence of an antibody derived light chain, wherein said amino acid sequence is a particularly identified amino acid sequence comprising specific amino acid substitutions, and a second domain is or contains at least one further antigen-interaction-site and/or at least one further effector domain. The invention further provides nucleic acid molecules encoding the bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Moreover, the invention concerns a method for the production of bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.
IPC 8 full level
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 31/00 (2006.01); A61P 33/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07K 16/30 (2006.01); C07K 16/46 (2006.01)
CPC (source: EP KR US)
A61P 29/00 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 33/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 37/08 (2018.01 - EP); C07K 16/18 (2013.01 - KR); C07K 16/28 (2013.01 - KR); C07K 16/2803 (2013.01 - EP US); C07K 16/2809 (2013.01 - EP US); C07K 16/30 (2013.01 - EP KR US); C07K 2317/31 (2013.01 - EP US); C07K 2317/34 (2013.01 - EP US); C07K 2317/622 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
WO 2005077982 A1 20050825; AT E477277 T1 20100815; AU 2005212830 A1 20050825; AU 2005212830 B2 20110602; BR PI0507649 A 20070710; CA 2555503 A1 20050825; CA 2555503 C 20180327; CN 1950399 A 20070418; DE 602005022830 D1 20100923; DK 1716178 T3 20100920; EP 1716178 A1 20061102; EP 1716178 B1 20100811; IL 177337 A0 20061210; JP 2008506353 A 20080306; JP 4762158 B2 20110831; KR 20060131892 A 20061220; MX PA06009253 A 20070418; RU 2006132669 A 20080327; SI 1716178 T1 20101130; US 2008213256 A1 20080904; US 8101722 B2 20120124; ZA 200606410 B 20071227
DOCDB simple family (application)
EP 2005001573 W 20050216; AT 05715354 T 20050216; AU 2005212830 A 20050216; BR PI0507649 A 20050216; CA 2555503 A 20050216; CN 200580008594 A 20050216; DE 602005022830 T 20050216; DK 05715354 T 20050216; EP 05715354 A 20050216; IL 17733706 A 20060807; JP 2006552576 A 20050216; KR 20067018976 A 20060915; MX PA06009253 A 20050216; RU 2006132669 A 20050216; SI 200531118 T 20050216; US 58873405 A 20050216; ZA 200606410 A 20050216