EP 1716900 A1 20061102 - Method and device for chromatographic purification
Title (en)
Method and device for chromatographic purification
Title (de)
Verfahren und Vorrichtung zur chromatographischen Reinigung
Title (fr)
Méthode et appareil pour purification par chromatographie
Publication
Application
Priority
- EP 05405327 A 20050429
- EP 05405421 A 20050701
Abstract (en)
A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent (s), is proposed. The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (±,²,³,´), in which the first section (±) is provided with at least one inlet of solvent (s) and at least one outlet for purified intermediate product (B), such that it washes the purified intermediate product (B) out of the system, but keeps the heavy impurities (C) inside the section (±), the second section (²) is provided with at least one inlet of solvent (s) and at least one outlet connected to an inlet of the fourth section (´), such that it washes the intermediate product (B), which is contaminated with heavy impurities (C) into the fourth section (´) through said outlet, but keeps the pure heavy impurities (C) inside the section (²), the third section (³) is provided with at least one inlet of solvent (s) and an outlet for heavy impurities (C), such that it washes out the heavy impurities (C) through said outlet and cleans the chromatographic column(s), the fourth section (´) is provided with at least one inlet to receive output of the outlet of the second section (²) as well as at least one inlet for feeding in the multi-component mixture (F) and at least one outlet for light impurities (A), such that it washes the light impurities (A) out of the system, but keeps the intermediate product (B) inside the section (8), wherein after or within a switch time (t*) the last column from the first section (±) is moved to the first position of the second section (²), the last column of the second section (²) is moved to the first position of the third section (³), the last column of the third section (³) is moved to the first position of the fourth section (´) and the last column of the fourth section (´) is moved to become the first column of the first section (±).
IPC 8 full level
B01D 15/18 (2006.01)
CPC (source: EP US)
B01D 15/1828 (2013.01 - EP US); B01D 15/1864 (2013.01 - EP US); G01N 30/468 (2013.01 - EP US)
Citation (applicant)
- WO 2004039468 A2 20040513 - NOVASEP [FR], et al
- WO 2004014511 A1 20040219 - MAX PLANCK GESELLSCHAFT [DE], et al
- US 4031155 A 19770621 - HEALY FRANK J, et al
- MARKUS JUZA; MARCO MAZZOTTI; MASSIMO MORBIDELLI: "TRENDS IN BIOTECHNOLOGY", vol. 18, March 2000, ELSEVIER B.V., TIBTECH, article "Simulated moving-bed chromatography and its application to chirotechnology", pages: 108 - 118
- ZIYANG ZHANG; MARCO MAZZOTTI; MASSIMO MORBIDELLI: "JOURNAL OF CHROMATOGRAPHY A", vol. 1006, 2003, ELSEVIER B.V., article "PowerFeed operation of simulated moving bed units: changing flow-rates during the switching interval", pages: 87 - 99
Citation (search report)
- [X] EP 0495640 A1 19920722 - SOKEN KAGAKU KK [JP]
- [X] US 2004063992 A1 20040401 - CHIANG CHEN-CHOU [US], et al
- [X] US 2004129137 A1 20040708 - CHIN NIEN-HWA LINDA [US], et al
- [A] US 2004241878 A1 20041202 - THOMMES JORG [US], et al
- [A] WO 0240129 A2 20020523 - PURDUE RESEARCH FOUNDATION [US], et al
- [A] US 5560827 A 19961001 - HESTER ROGER D [US], et al
- [X] GOTTSCHLICH N ET AL: "Purification of monoclonal antibodies by simulated moving-bed chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 765, no. 2, 28 March 1997 (1997-03-28), pages 201 - 206, XP004059238, ISSN: 0021-9673
- [X] GOTTSCHLICH N ET AL: "Continuous biospecific affinity purification of enzymes by simulated moving-bed chromatography Theoretical description and experimental results", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 719, no. 2, 8 January 1996 (1996-01-08), pages 267 - 274, XP004038443, ISSN: 0021-9673
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006116886 A1 20061109; AT E492804 T1 20110115; CN 101166564 A 20080423; CN 101166564 B 20101208; DE 602006019082 D1 20110203; DK 1877769 T3 20110328; EP 1716900 A1 20061102; EP 1877769 A1 20080116; EP 1877769 B1 20101222; JP 2008539395 A 20081113; JP 5133872 B2 20130130; US 2009050567 A1 20090226; US 2011042310 A1 20110224; US 7837881 B2 20101123; US 8496836 B2 20130730
DOCDB simple family (application)
CH 2006000232 W 20060427; AT 06721934 T 20060427; CN 200680014151 A 20060427; DE 602006019082 T 20060427; DK 06721934 T 20060427; EP 05405421 A 20050701; EP 06721934 A 20060427; JP 2008508046 A 20060427; US 91636710 A 20101029; US 91954006 A 20060427