Global Patent Index - EP 1718335 A4

EP 1718335 A4 20101110 - DRUG CONJUGATES

Title (en)

DRUG CONJUGATES

Title (de)

ARZNEIMITTELKONJUGATE

Title (fr)

CONJUGUES DE MEDICAMENTS

Publication

EP 1718335 A4 20101110 (EN)

Application

EP 05723074 A 20050211

Priority

  • US 2005004715 W 20050211
  • US 54403304 P 20040212

Abstract (en)

[origin: WO2005079398A2] A compound having the formula Y - A - Z, wherein: A is a 5, 6, or 7 member ring that is monocyclic or is fused to 1 to 3 additional 4 to 8 member rings; wherein ring A and, independently, the fused additional rings are carbocyclic or heterocyclic, and saturated or unsaturated, wherein unsaturated rings are aromatic or non-aromatic; whereinY and Z are substituents at adjacent positions on ring A; Y represents Formula (I); Z represents Formula (II); X and E represent O, S, or NR<a> or NR<b>; each of a, b, c, d, e and f independently represents 0 or 1; a + c equals 0, 1, or 2; b + d equals 0, 1, or 2; a + b + c + d + e + f equals 1, 2, or 3; provided that when f is 1, then d is 1, and when d is 0, then f is 0; and when both e and b are 0, then neither R<1> nor R<2> is chloro or bromo; v represents 0 or 1, provided that when v is 0, then J is hydrogen, a metal ion, or a quaternary ammonium ion; and X is O and G is H; either G is hydrogen, a metal ion, a quaternary ammonium ion, lower alkyl, or comprised of a pharmaceutically active chemical compound or the precursor thereof; or X-G represents a carbonyl-activating group; J is lower alkyl, aryl, heteroaryl, omega-hydroxycarbonyl-(lower alkyl), omega-(lower alkoxy)carbonyl-(lower alkyl), omega-(X-G)-carbonyl-(lower alkyl) group, or compromised of a specific binding agent; and R<a>, R<b>, R<1>, R<2>, R<3>, R<4> are as defined in the specification.

IPC 8 full level

A61K 31/01 (2006.01); A61K 31/33 (2006.01); A61K 31/435 (2006.01); A61K 39/395 (2006.01); A61K 39/44 (2006.01); A61K 47/48 (2006.01); C07C 15/04 (2006.01); C07C 323/62 (2006.01); C07D 213/00 (2006.01); C07D 213/30 (2006.01); C07D 213/32 (2006.01); C07D 213/71 (2006.01); C07D 305/14 (2006.01); C07K 16/46 (2006.01)

CPC (source: EP US)

A61K 47/6803 (2017.07 - EP US); A61K 47/6889 (2017.07 - EP US); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 323/62 (2013.01 - EP US); C07D 213/71 (2013.01 - EP US); C07D 305/14 (2013.01 - EP US)

Citation (search report)

  • [X] EP 0242070 A2 19871021 - ICI PLC [GB]
  • [XY] CS 191792 B1 19790731 - SINDELAR KAREL, et al
  • [Y] WO 0138318 A1 20010531 - IMMUNOGEN INC [US]
  • [XY] PASCAL I, TARBELL S D: "The kinetics of the oxidation of a mercaptan to the corresponding disulfide by aqeuous hydrogen peroxide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, no. 22, November 1959 (1959-11-01), pages 6015 - 6020, XP002602050, DOI: 10.1021/ja01579a045
  • [X] SINDELAR K ET AL: "SYNTHESIS OF 3-CHLORO-5-(4-METHYLPIPERAZINO)-6,7-DIHYDRO-5H-DIBENZOÄB ,GÜTHIOCIN, AN EIGHT-MEMBERED RING HOMOLOGUE OF THE NEUROLEPTIC AGENT OCTOCLOTHEPIN", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, INSTITUTE OF ORGANIC CHEMISTRY & BIOCHEMISTRY, PRAGUE; CZ, vol. 45, 1 January 1980 (1980-01-01), pages 491 - 503, XP009065554, ISSN: 0010-0765
  • [X] BLOCK E ET AL: "Antithrombotic organosulfur compounds from garlic: structural, mechanistic and synthetic studies", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 108, no. 22, October 1986 (1986-10-01), pages 7045 - 7055, XP002602051, DOI: 10.1021/ja00282a033
  • [X] DOMAGALA J M ET AL: "2,2'-DITHIOBISBENZAMIDES AND 2-BENZISOTHIAZOLONES, TWO NEW CLASSES OF ANTIRETROVIRAL AGENTS: SAR AND MECHANISTIC CONSIDERATIONS", DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS INC, US, vol. 15, no. 1, 1 January 1997 (1997-01-01), pages 49 - 61, XP001036902, ISSN: 1055-9612
  • [Y] VRUDHULA V M ET AL: "Reductively activated disulfide prodrugs of paclitaxel", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 200212 GB LNKD- DOI:10.1016/S0960-894X(02)00784-9, vol. 12, no. 24, December 2002 (2002-12-01), pages 3591 - 3594, XP002602052, ISSN: 0960-894X
  • [A] NORBECK D W ET AL: "A novel prodrug of an impermeant inhibitor of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase has antibacterial activity", JOURNAL OF MEDICINAL CHEMISTRY 1989 US, vol. 32, no. 3, 1989, pages 625 - 629, XP002602053, ISSN: 0022-2623
  • [A] SAITO G ET AL: "Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities", ADVANCED DRUG DELIVERY REVIEWS 20030210 NL LNKD- DOI:10.1016/S0169-409X(02)00179-5, vol. 55, no. 2, 10 February 2003 (2003-02-10), pages 199 - 215, XP002602054, ISSN: 0169-409X
  • See references of WO 2005079398A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005079398 A2 20050901; WO 2005079398 A3 20051229; AU 2005214905 A1 20050901; CA 2555641 A1 20050901; CN 1933853 A 20070321; CN 1933853 B 20100512; EP 1718335 A2 20061108; EP 1718335 A4 20101110; JP 2007522245 A 20070809; JP 5259087 B2 20130807; US 2005232928 A1 20051020; US 2008139815 A1 20080612; US 7282590 B2 20071016; US 7847119 B2 20101207

DOCDB simple family (application)

US 2005004715 W 20050211; AU 2005214905 A 20050211; CA 2555641 A 20050211; CN 200580009264 A 20050211; EP 05723074 A 20050211; JP 2006553334 A 20050211; US 5365505 A 20050208; US 85631707 A 20070917