EP 1718979 A2 20061108 - METHODS OF SCREENING USING CTGF AND TRKA RECEPTOR FOR THE IDENTIFICATION OF COMPOUNDS FOR USE IN TREATMENT OF FIBROSIS
Title (en)
METHODS OF SCREENING USING CTGF AND TRKA RECEPTOR FOR THE IDENTIFICATION OF COMPOUNDS FOR USE IN TREATMENT OF FIBROSIS
Title (de)
SCREENINGVERFAHREN MIT CTGF UND TRKA ZUM IDENTIFIZIEREN VON VERBINDUNGEN FUR DIE BEHANDLUNG VON FIBROSE
Title (fr)
METHODES DE CRIBLAGE UTILISANT LE CTGF ET LE RECEPTEUR TRKA POUR L'IDENTIFICATION DE COMPOSES POUR LE TRAITEMENT DE LA FIBROSE
Publication
Application
Priority
- GB 2004004795 W 20041115
- GB 0326780 A 20031118
Abstract (en)
[origin: WO2005050203A2] The invention provides a method for identifying and/or making compounds for use in reducing and/or preventing fibrosis, comprising the steps: providing a CTGF receptor; providing a test sample; providing a CTGF receptor agonist; exposing the CTGF receptor to the test sample; subsequently or simultaneously exposing the CTGF receptor to the CTGF receptor agonist; detecting and/or measuring the amount of CTGF receptor activation; comparing the amount of CTGF receptor activation detected and/or measured in the presence of the test sample with the amount of CTGF receptor activation detected and/or measured in the absence of a test sample; determining if a compound reduces and/or prevents fibrosis on the basis that it causes no increase or a decrease in CTGF receptor activation. There is also provided compounds for reducing and/or preventing fibrosis and uses of such compounds.
IPC 8 full level
G01N 33/74 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 13/12 (2017.12); A61P 17/00 (2017.12); A61P 21/00 (2017.12); A61P 27/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); G01N 33/74 (2013.01); G01N 2333/71 (2013.01)
Citation (search report)
See references of WO 2005050203A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005050203 A2 20050602; WO 2005050203 A3 20051117; AU 2004292013 A1 20050602; CA 2546401 A1 20050602; CN 1906491 A 20070131; EP 1718979 A2 20061108; GB 0326780 D0 20031224; JP 2007515162 A 20070614
DOCDB simple family (application)
GB 2004004795 W 20041115; AU 2004292013 A 20041115; CA 2546401 A 20041115; CN 200480040637 A 20041115; EP 04798515 A 20041115; GB 0326780 A 20031118; JP 2006540577 A 20041115