Global Patent Index - EP 1721982 A1

EP 1721982 A1 20061115 - Chimeric lyssavirus nucleic acids and polypeptides

Title (en)

Chimeric lyssavirus nucleic acids and polypeptides

Title (de)

Chimäre Nukleinsäuren und Polypeptide aus Iyssavirus

Title (fr)

Acides nucléiques et polypeptides chimères de Lyssavirus

Publication

EP 1721982 A1 20061115 (EN)

Application

EP 06112582 A 20000417

Priority

  • EP 00917245 A 20000417
  • US 12950199 P 19990415

Abstract (en)

The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a lyssavirus glycoprotein, which has been found to improve the immunogenicity of lyssavirus epitopes for protection from rabies. The chimeric nucleic acids and proteins can also contain antigenic determinants for epitopes other than those of lyssavirus. Thus, the invention provides chimeric nucleic acids and polypeptides that elicit a strong immune response to multiple antigens. Use of the methods of the present invention permits DNA vaccination without the need to supply multiple antigens on separate DNA molecules.

IPC 8 full level

C12N 15/47 (2006.01); A61K 39/205 (2006.01); C07K 14/145 (2006.01); C12N 15/62 (2006.01); A61K 35/00 (2006.01)

CPC (source: EP)

C07K 14/005 (2013.01); A61K 35/00 (2013.01); C07K 2319/00 (2013.01); C12N 2760/20122 (2013.01); C12N 2760/20134 (2013.01)

Citation (applicant)

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Citation (search report)

  • [X] JALLET C. ET AL.: "Chimeric lyssavirus glycoproteins with increased immunological potential.", J VIROL 1999 JAN;73(1):225-33, January 1999 (1999-01-01), XP002145722
  • [X] BAHLOUL C. ET AL.: "DNA-based immunization for exploring the enlargement of immunological oss-reactivity against the lyssaviruses.", VACCINE 1998 FEB;16(4):417-25, February 1998 (1998-02-01), XP004099304
  • [PX] DESMEZIERES E. ET AL.: "Lyssavirus glycoproteins expressing immunologically potent foreign B cell d cytotoxic T lymphocyte epitopes as prototypes for multivalent ccines.", J GEN VIROL 1999 SEP;80 ( PT 9):2343-51, September 1999 (1999-09-01), XP002145723

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

EP 1721982 A1 20061115; EP 1721982 B1 20130410

DOCDB simple family (application)

EP 06112582 A 20000417