Title (en)

SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS

Title (de)

AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL

Title (fr)

ANTAGONISTES DE CGRP SELECTIONNES, PROCEDES DE FABRICATION ET UTILISATION EN TANT QUE MEDICAMENT

Publication

EP 1722792 A1 20061122 (DE)

Application

EP 05715592 A 20050226

Priority

• EP 2005002082 W 20050226
• DE 102004010254 A 20040303
• DE 102004028751 A 20040615

Abstract (en)

[origin: WO2005084672A1] The invention relates to substituted piperidines of general formula (I), wherein A, B, D, E, X, R<1> and R<2> have the meaning cited in claim 1, and to the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof, in addition to the hydrate of the salts, in particular the physiologically compatible salts thereof having inorganic or organic acids. The invention also relates to medicaments containing said compounds, to the use thereof and method for the production thereof.

IPC 8 full level

A61K 31/435 (2006.01); A61K 31/445 (2006.01); A61K 31/4545 (2006.01); A61K 31/54 (2006.01); A61K 31/55 (2006.01); A61P 5/00 (2006.01); C07D 401/14 (2006.01)

CPC (source: EP US)

A61P 5/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); C07D 401/14 (2013.01 - EP US)

Citation (search report)

See references of WO 2005084672A1

Citation (examination)

BURGEY C.S. ET AL: "Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Opimization of the 4-substituted piperidine", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 5052 - 5056

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

BA HR YU

DOCDB simple family (publication)

WO 2005084672 A1 20050915; EP 1722792 A1 20061122; US 2005227968 A1 20051013; US 7205294 B2 20070417

DOCDB simple family (application)

EP 2005002082 W 20050226; EP 05715592 A 20050226; US 7334105 A 20050303