EP 1727832 A2 20061206 - ANTIGEN OF THE PM-2 ANTIBODY AND USE THEREOF
Title (en)
ANTIGEN OF THE PM-2 ANTIBODY AND USE THEREOF
Title (de)
ANTIGEN DES PM-2 ANTIKÖRPERS UND DESSEN VERWENDUNG
Title (fr)
ANTIGENE DE L'ANTICORPS PM-2 ET SON UTILISATION
Publication
Application
Priority
- DE 2005000455 W 20050310
- DE 102004015179 A 20040325
Abstract (en)
[origin: WO2005092922A2] The invention relates to a polypeptide, which is expressed on the cell surface as a membrane-bound protein, is glycolyzed at one or more points (membrane glycoprotein) and whose amino acid sequence corresponds partially or completely to that of the integrin binding protein p80 (accession # AJ131720) or REV1 (accession # AF206019). The membrane glycoprotein is expressed by neoplastic cells and not by non-neoplastic cells and as an antigen specifically binds the human monoclonal antibody PM-2 (DSM number: DSM ACC2600) and is in addition N-glycosidically and O-glucosidically linked. The invention also relates to a method for the isolation or production of the antigen and to the use of the latter for producing a medicament for immunization. The isolated antigen is also used to identify medicaments with an apoptotic or cell-proliferation inhibiting action. The invention also relates to the use of the membrane glycoprotein as a tumour marker.
IPC 8 full level
C07K 14/47 (2006.01); A61K 39/00 (2006.01); A61K 49/14 (2006.01); C07K 1/14 (2006.01); C07K 14/705 (2006.01); C12N 15/63 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61P 35/00 (2018.01 - EP); C07K 14/47 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
WO 2005092922 A2 20051006; WO 2005092922 A3 20060727; DE 102004015179 A1 20051013; DE 112005001260 A5 20070531; EP 1727832 A2 20061206; JP 2008502321 A 20080131; US 2008281083 A1 20081113
DOCDB simple family (application)
DE 2005000455 W 20050310; DE 102004015179 A 20040325; DE 112005001260 T 20050310; EP 05735145 A 20050310; JP 2007508715 A 20050310; US 59929705 A 20050310