EP 1734983 A2 20061227 - MODIFIED ANNEXIN PROTEINS AND METHODS FOR PREVENTING THROMBOSIS
Title (en)
MODIFIED ANNEXIN PROTEINS AND METHODS FOR PREVENTING THROMBOSIS
Title (de)
MODIFIZIERTE ANNEXIN-PROTEINE UND VERFAHREN ZUR VERHINDERUNG VON THROMBOSE
Title (fr)
PROTEINES D'ANNEXINE MODIFIEES ET PROCEDES DESTINES A PREVENIR LA THROMBOSE
Publication
Application
Priority
- US 2005008193 W 20050310
- US 55242804 P 20040311
- US 57958904 P 20040614
Abstract (en)
[origin: WO2005086955A2] A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing hemorrhage. Annexin binds to phosphatidylserine on the outer surface of cell membranes, thereby preventing binding of the prothrombinase complex necessary for thrombus formation. It does not, however, affect platelet aggregation necessary for hemostasis. The modified annexin molecule can be a homodimer of annexin, an annexin molecule coupled to one or more polyethylene glycol chains, or an annexin molecule coupled to another protein. By increasing the molecular weight of annexin, the modified annexin is made to remain in circulation for sufficient time to provide a sustained therapeutic effect.
IPC 8 full level
A61K 38/17 (2006.01); A61P 7/02 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); C07K 14/4721 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005086955 A2 20050922; WO 2005086955 A3 20060309; AU 2005221195 A1 20050922; AU 2005221195 B2 20110519; CA 2559167 A1 20050922; EP 1734983 A2 20061227; EP 1734983 A4 20091118; JP 2008502592 A 20080131; JP 2012254992 A 20121227; JP 5134362 B2 20130130
DOCDB simple family (application)
US 2005008193 W 20050310; AU 2005221195 A 20050310; CA 2559167 A 20050310; EP 05725390 A 20050310; JP 2007503052 A 20050310; JP 2012161761 A 20120720