Global Patent Index - EP 1734983 A4

EP 1734983 A4 20091118 - MODIFIED ANNEXIN PROTEINS AND METHODS FOR PREVENTING THROMBOSIS

Title (en)

MODIFIED ANNEXIN PROTEINS AND METHODS FOR PREVENTING THROMBOSIS

Title (de)

MODIFIZIERTE ANNEXIN-PROTEINE UND VERFAHREN ZUR VERHINDERUNG VON THROMBOSE

Title (fr)

PROTEINES D'ANNEXINE MODIFIEES ET PROCEDES DESTINES A PREVENIR LA THROMBOSE

Publication

EP 1734983 A4 20091118 (EN)

Application

EP 05725390 A 20050310

Priority

  • US 2005008193 W 20050310
  • US 55242804 P 20040311
  • US 57958904 P 20040614

Abstract (en)

[origin: WO2005086955A2] A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing hemorrhage. Annexin binds to phosphatidylserine on the outer surface of cell membranes, thereby preventing binding of the prothrombinase complex necessary for thrombus formation. It does not, however, affect platelet aggregation necessary for hemostasis. The modified annexin molecule can be a homodimer of annexin, an annexin molecule coupled to one or more polyethylene glycol chains, or an annexin molecule coupled to another protein. By increasing the molecular weight of annexin, the modified annexin is made to remain in circulation for sufficient time to provide a sustained therapeutic effect.

IPC 8 full level

A61K 38/17 (2006.01); A61P 7/02 (2006.01)

CPC (source: EP)

A61P 7/02 (2017.12); C07K 14/4721 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [X] WO 02067857 A2 20020906 - SURROMED INC [US]
  • [X] WO 2004013303 A2 20040212 - SURROMED INC [US]
  • [T] SHEN X-D ET AL: "Diannexin, A Novel Annexin V Homodimer, Protects Rat Liver Transplants Against Cold Ischemia Reperfusion Injury", AMERICAN JOURNAL OF TRANSPLANTATION, BLACKWELL MUNKSGAARD, DK, vol. 7, no. 11, 1 November 2007 (2007-11-01), pages 2463 - 2471, XP008101571, ISSN: 1600-6135, [retrieved on 20071009]
  • [PX] WOLBERG ALISA S ET AL: "Annexin A2: better left alone.", BLOOD 1 MAR 2005, vol. 105, no. 5, 1 March 2005 (2005-03-01), pages 1845 - 1846, XP002547852, ISSN: 0006-4971
  • [T] KUYPERS FRANS A ET AL: "Interaction of an annexinV homodimer (Diannexin) with phosphatidylserine on cell surfaces and consequent antithrombotic activity", THROMBOSIS AND HAEMOSTASIS, vol. 97, no. 3, March 2007 (2007-03-01), pages 478 - 486, XP009123428, ISSN: 0340-6245
  • See references of WO 2005086955A2

Citation (examination)

  • US 2003152513 A1 20030814 - BLANKENBERG FRANCIS G [US], et al
  • JIE LIU ET AL: "Annexin V assay-proven anti-apoptotic effect of ascorbic acid 2-glucoside after cold ischemia/reperfusion injury in rat liver transplantation.", ACTA MEDICA OKAYAMA, vol. 57, no. 5, 1 October 2003 (2003-10-01), pages 209 - 216, XP055051694, ISSN: 0386-300X
  • TODUKA MASAYUKI ET AL: "Mobilization of cardiac annexin V during ischemia and ischemic reperfusion", DOKKYO JOURNAL OF MEDICAL SCIENCES, MIBU, JP, vol. 27, no. 1, 1 March 2000 (2000-03-01), pages 253 - 260, XP009166718, ISSN: 0385-5023
  • LA ET AL: "Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action", THE FASEB JOURNAL, vol. 15, no. 12, 1 October 2001 (2001-10-01), pages 2247 - 2256, XP055000646, ISSN: 0892-6638, DOI: 10.1096/fj.01-0196com
  • TEOH ET AL: "Diannexin, a Novel Annexin V Homodimer, Provides Prolonged Protection Against Hepatic Ischemia-Reperfusion Injury in Mice", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 133, no. 2, 3 August 2007 (2007-08-03), pages 632 - 646, XP022198888, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2007.05.027
  • KIMBERLEY E. WEVER ET AL: "Diannexin Protects against Renal Ischemia Reperfusion Injury and Targets Phosphatidylserines in Ischemic Tissue", PLOS ONE, vol. 6, no. 8, 1 January 2011 (2011-01-01), pages e24276, XP055031079, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0024276

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005086955 A2 20050922; WO 2005086955 A3 20060309; AU 2005221195 A1 20050922; AU 2005221195 B2 20110519; CA 2559167 A1 20050922; EP 1734983 A2 20061227; EP 1734983 A4 20091118; JP 2008502592 A 20080131; JP 2012254992 A 20121227; JP 5134362 B2 20130130

DOCDB simple family (application)

US 2005008193 W 20050310; AU 2005221195 A 20050310; CA 2559167 A 20050310; EP 05725390 A 20050310; JP 2007503052 A 20050310; JP 2012161761 A 20120720