EP 1734994 A1 20061227 - SITE-SPECIFIC CHEMICAL MODIFICATION OF HIV GP41-DERIVED PEPTIDES
Title (en)
SITE-SPECIFIC CHEMICAL MODIFICATION OF HIV GP41-DERIVED PEPTIDES
Title (de)
SITUSSPEZIFISCHE CHEMISCHE MODIFIZIERUNG VON PEPTIDEN VON HIV GP41-
Title (fr)
MODIFICATION CHIMIQUE SPECIFIQUE DE SITE DE PEPTIDES DERIVES DE GP41 DU VIH
Publication
Application
Priority
- US 2005007486 W 20050308
- US 55306304 P 20040315
Abstract (en)
[origin: WO2005089796A1] Provided is a method for site-specific chemical modification of an HIV gp41 -derived peptide, wherein during synthesis one or more amine groups of the HIV gp41 -derived peptide are chosen to blocked by a chemical protecting agent, and one or more amine groups are selected to be unprotected, and remain free to be reacted with an amine reactive functionality. The resultant HIV gp41-derived peptide may be used to produce a substantially homogeneous conjugate comprised of HIV gp41-derived peptide and polymer by covalently coupling the polymer to the one or more free (unprotected) amine groups of the HIV gp41-derived peptide.
IPC 8 full level
A61K 39/21 (2006.01); A61K 47/48 (2006.01)
CPC (source: EP)
A61K 47/60 (2017.07); A61P 31/18 (2017.12)
Citation (search report)
See references of WO 2005089796A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005089796 A1 20050929; CA 2556032 A1 20050929; CN 1929860 A 20070314; EP 1734994 A1 20061227; IL 177268 A0 20061210; JP 2007529522 A 20071025
DOCDB simple family (application)
US 2005007486 W 20050308; CA 2556032 A 20050308; CN 200580007348 A 20050308; EP 05724921 A 20050308; IL 17726806 A 20060803; JP 2007503945 A 20050308