EP 1737426 A2 20070103 - CHOLINESTERASE INHIBITORS IN LIPOSOMES AND THEIR PRODUCTION AND USE
Title (en)
CHOLINESTERASE INHIBITORS IN LIPOSOMES AND THEIR PRODUCTION AND USE
Title (de)
CHOLINESTERASE-INHIBITOREN IN LIPOSOMEN SOWIE DEREN HERSTELLUNG UND VERWENDUNG
Title (fr)
INHIBITEURS DE LA CHOLINESTERASE INCLUS DANS DES LIPOSOMES, LEUR PRODUCTION ET LEUR UTILISATION
Publication
Application
Priority
- AT 2005000138 W 20050421
- AT 6962004 A 20040422
Abstract (en)
[origin: WO2005102268A2] The invention relates to a pharmaceutical composition based on an active ingredient that is enclosed in liposomes for topical, transdermal application. The interior of said liposomes comprises an acidic, aqueous medium containing at least one cholinesterase inhibitor, preferably from the group containing donepezil, rivastigmine, galantamine, physostigmine, heptylphysostigmine, phenserine, tolserine, cymserine, thiatolserine, thiacymserine, neostigmine, huperzine, tacrine, metrifonate and dichlorvos, or an enantiomer or derivative of at least one of said compounds. In addition, the invention relates to a method for producing said composition, optionally in a sterile form and also to the use of the liposomes charged with the active ingredient in various galenic formulations for topical, transdermal application with a depot effect in the epidermis, for the prophylaxis and/or treatment of cutaneous neuropathic pain or the loss of cutaneous sensory function as a result of neuropathy.
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/127 (2006.01)
CPC (source: EP US)
A61K 9/127 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (search report)
See references of WO 2005102268A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
WO 2005102268 A2 20051103; WO 2005102268 A3 20060406; AT 500143 A1 20051115; AU 2005235430 A1 20051103; CA 2563861 A1 20051103; CN 1946377 A 20070411; EP 1737426 A2 20070103; JP 2007533666 A 20071122; NO 20065339 L 20070109; RU 2006141254 A 20080527; US 2008031935 A1 20080207
DOCDB simple family (application)
AT 2005000138 W 20050421; AT 6962004 A 20040422; AU 2005235430 A 20050421; CA 2563861 A 20050421; CN 200580012561 A 20050421; EP 05731917 A 20050421; JP 2007508671 A 20050421; NO 20065339 A 20061121; RU 2006141254 A 20050421; US 57819105 A 20050421