Title (en)

MICRO RNA INHIBITING THE EXPRESSION OF WT1 GENE AND UTILIZATION OF THE SAME

Title (de)

MIKRO-RNA ZUR HEMMUNG DER EXPRESSION DES WT1-GENS UND IHRE VERWENDUNG

Title (fr)

MICRO ARN INHIBANT L'EXPRESSION DU GENE WT1 ET UTILISATION DE CELUI-CI

Publication

EP 1738772 A4 20071226 (EN)

Application

EP 05727699 A 20050328

Priority

• JP 2005005790 W 20050328
• JP 2004096877 A 20040329

Abstract (en)

[origin: EP1738772A1] It was found that miRNA that targets the vicinity of the WT1 gene stop codon not only suppresses the expression of the WT1 gene, but also exhibits a marked effect of suppressing cell growth in cancer cell lines.

IPC 8 full level

A61K 48/00 (2006.01); A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 35/76 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C12N 15/09 (2006.01); C12N 15/113 (2010.01)

CPC (source: EP US)

A61K 31/7105 (2013.01 - EP US); A61K 31/711 (2013.01 - EP US); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C12N 15/113 (2013.01 - EP US); C12N 2310/14 (2013.01 - EP US)

Citation (search report)

• [E] EP 1738771 A1 20070103 - SUGIYAMA HARUO [JP]
• [X] EP 1004319 A1 20000531 - SUGIYAMA HARUO [JP]
• [X] EP 0841068 A1 19980513 - KISHIMOTO TADAMITSU [JP]
• [X] HÜBINGER G ET AL: "Ribozyme-mediated cleavage of wt1 transcripts suppresses growth of leukemia cells.", EXPERIMENTAL HEMATOLOGY OCT 2001, vol. 29, no. 10, October 2001 (2001-10-01), pages 1226 - 1235, XP002458405, ISSN: 0301-472X
• See also references of WO 2005092393A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1738772 A1 20070103; EP 1738772 A4 20071226; JP 4762133 B2 20110831; JP WO2005092393 A1 20080207; US 2008038819 A1 20080214; WO 2005092393 A1 20051006

DOCDB simple family (application)

EP 05727699 A 20050328; JP 2005005790 W 20050328; JP 2006511568 A 20050328; US 59470605 A 20050328