EP 1740221 A4 20090107 - METHODS AND COMPOSITIONS FOR THE TREATMENT OF POLYCYSTIC DISEASES
Title (en)
METHODS AND COMPOSITIONS FOR THE TREATMENT OF POLYCYSTIC DISEASES
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON POLYZYSTISCHEN ERKRANKUNGEN
Title (fr)
PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DES MALADIES POLYKYSTIQUES
Publication
Application
Priority
- US 2005014982 W 20050429
- US 56667004 P 20040429
- US 59038504 P 20040722
Abstract (en)
[origin: WO2005117941A2] This invention provides compositions and methods to diagnose and treat polycystic disorders by inhibiting the biological activity of a gene now correlated with appearance of this disorder. By way of illustrative only, the Connective Tissue Growth Factor (CTGF) gene is an example of such a gene. Also provided by this invention are compositions and methods to treat or ameliorate abnormal cystic lesions and diseases associated with the formation of cysts in tissue. The methods and compositions treat and ameliorate pathological cyst formation in tissue by inhibiting or augmenting gene expression or the biological activity of its gene expression product or its receptor.
IPC 8 full level
A61K 39/395 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); A61P 13/12 (2006.01); C07K 16/22 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 1/18 (2017.12); A61P 3/12 (2017.12); A61P 9/00 (2017.12); A61P 9/12 (2017.12); A61P 13/02 (2017.12); A61P 13/12 (2017.12); A61P 15/08 (2017.12); A61P 25/02 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); C07K 16/22 (2013.01); A61K 2039/505 (2013.01)
Citation (search report)
- [A] WO 03024308 A2 20030327 - FIBROGEN INC [US], et al
- [A] EP 1043335 A1 20001011 - JAPAN TOBACCO INC [JP], et al
- [A] WO 03053340 A2 20030703 - ISIS PHARMACEUTICALS INC [US], et al
- [XA] HUSSON H ET AL: "Combination of SAGE and custom microarray technologies for expression profiling of normal and ADPKD epithelia", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 13, no. Program and Abstracts Issue, 4 October 2002 (2002-10-04), pages 117A, XP008098855, ISSN: 1046-6673
- [X] DELL K M ET AL: "A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 60, no. 4, 1 October 2001 (2001-10-01), pages 1240 - 1248, XP002223746, ISSN: 0085-2538
- See references of WO 2005117941A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005117941 A2 20051215; WO 2005117941 A3 20060518; BR PI0510367 A 20071106; CA 2564092 A1 20051215; EP 1740221 A2 20070110; EP 1740221 A4 20090107; JP 2007535562 A 20071206; MX PA06012446 A 20070117
DOCDB simple family (application)
US 2005014982 W 20050429; BR PI0510367 A 20050429; CA 2564092 A 20050429; EP 05804799 A 20050429; JP 2007511046 A 20050429; MX PA06012446 A 20050429