EP 1742961 A2 20070117 - INHIBITION OF FGF SIGNALING
Title (en)
INHIBITION OF FGF SIGNALING
Title (de)
SPERRUNG DER FGF-SIGNALISIERUNG
Title (fr)
INHIBITION DE LA SIGNALISATION DU FGF
Publication
Application
Priority
- US 2005004682 W 20050211
- US 54444904 P 20040213
Abstract (en)
[origin: US2005227921A1] Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
IPC 8 full level
C07K 1/00 (2006.01); A61K 38/18 (2006.01); A61K 38/46 (2006.01)
CPC (source: EP US)
A61K 31/727 (2013.01 - EP US); A61K 38/465 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12Y 301/06 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
US 2005227921 A1 20051013; US 7968527 B2 20110628; CA 2555417 A1 20050901; EP 1742961 A2 20070117; EP 1742961 A4 20090715; JP 2007522243 A 20070809; WO 2005079390 A2 20050901; WO 2005079390 A3 20061214
DOCDB simple family (application)
US 5739005 A 20050211; CA 2555417 A 20050211; EP 05713533 A 20050211; JP 2006553327 A 20050211; US 2005004682 W 20050211