EP 1743885 B1 20091111 - 1-[(adamantyl)alkyl]-3-[(pyridinyl)alkyl]urea compounds as TNF-.alpha inhibitors useful for autoimmune diseases
Title (en)
1-[(adamantyl)alkyl]-3-[(pyridinyl)alkyl]urea compounds as TNF-.alpha inhibitors useful for autoimmune diseases
Title (de)
1-[(adamantyl)alkyl]-3-[(pyridinyl)alkyl]Harnstoff-Verbindungen als TNF-.alpha Hemmer zur Behandlung von Autoimmunerkrankungen
Title (fr)
Composés de 1-[(adamantyl)alkyl]-3-[(pyridinyl)alkyl]urée comme inhibiteurs de la production de TNF-.alpha utiles pour le traitement de maladies autoimmunes
Publication
Application
Priority
- EP 01934447 A 20010531
- JP 2000162945 A 20000531
Abstract (en)
[origin: US2003032623A1] A purpose of the present invention is to provide TNF-alpha production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-alpha production inhibitory activities, wherein "A" is -(NR4)-, -(CR5R6)- or -O-, "B" is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and "X" is oxygen or sulfer respectively.
IPC 8 full level
C07D 213/40 (2006.01); C07D 233/61 (2006.01); A61K 31/16 (2006.01); A61K 31/18 (2006.01); A61K 31/417 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4418 (2006.01); A61K 31/4425 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/4525 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07C 275/24 (2006.01); C07C 311/39 (2006.01); C07D 213/30 (2006.01); C07D 213/32 (2006.01); C07D 213/36 (2006.01); C07D 213/38 (2006.01); C07D 213/55 (2006.01); C07D 213/56 (2006.01); C07D 213/59 (2006.01); C07D 213/68 (2006.01); C07D 213/74 (2006.01); C07D 213/75 (2006.01); C07D 215/12 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP KR US)
A61P 1/00 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 213/30 (2013.01 - EP US); C07D 213/32 (2013.01 - EP US); C07D 213/38 (2013.01 - EP US); C07D 213/40 (2013.01 - EP KR US); C07D 213/56 (2013.01 - EP US); C07D 213/68 (2013.01 - EP US); C07D 213/75 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
US 2003032623 A1 20030213; US 7098226 B2 20060829; AT E358122 T1 20070415; AT E374186 T1 20071015; AT E448204 T1 20091115; AT E481385 T1 20101015; AU 2001260674 B2 20060330; AU 2006200864 A1 20060323; AU 2006200864 B2 20071206; AU 6067401 A 20011211; CA 2409741 A1 20011206; CA 2409741 C 20111101; CA 2736344 A1 20011206; CN 1284771 C 20061115; CN 1307159 C 20070328; CN 1324012 C 20070704; CN 1432000 A 20030723; CN 1590374 A 20050309; CN 1590375 A 20050309; CY 1107089 T1 20121024; DE 60127595 D1 20070510; DE 60127595 T2 20080110; DE 60130658 D1 20071108; DE 60130658 T2 20080131; DE 60140495 D1 20091224; DE 60143098 D1 20101028; DK 1302461 T3 20080128; EP 1302461 A1 20030416; EP 1302461 A4 20040526; EP 1302461 B1 20070926; EP 1561749 A1 20050810; EP 1561749 B1 20070328; EP 1568692 A1 20050831; EP 1568692 B1 20100915; EP 1743885 A2 20070117; EP 1743885 A3 20070314; EP 1743885 B1 20091111; ES 2284138 T3 20071101; ES 2293993 T3 20080401; ES 2339141 T3 20100517; ES 2353020 T3 20110224; JP 2002053555 A 20020219; JP 2006213739 A 20060817; JP 2010059204 A 20100318; JP 2010059205 A 20100318; JP 3867196 B2 20070110; JP 4482735 B2 20100616; KR 100880698 B1 20090202; KR 100978304 B1 20100826; KR 20030007762 A 20030123; KR 20080093166 A 20081020; NO 20025718 D0 20021128; NO 20025718 L 20021128; NO 20073371 L 20021128; NO 324472 B1 20071029; PT 1302461 E 20071213; US 2006229342 A1 20061012; US 2006241155 A1 20061026; US 2008182881 A1 20080731; US 2010016380 A1 20100121; US 7345064 B2 20080318; US 7491739 B2 20090217; US 7923461 B2 20110412; WO 0192229 A1 20011206
DOCDB simple family (application)
US 16877702 A 20020621; AT 01934447 T 20010531; AT 05290274 T 20010531; AT 05290275 T 20010531; AT 06076696 T 20010531; AU 2001260674 A 20010531; AU 2006200864 A 20060228; AU 6067401 A 20010531; CA 2409741 A 20010531; CA 2736344 A 20010531; CN 01810233 A 20010531; CN 200410054674 A 20010531; CN 200410054677 A 20010531; CY 071101588 T 20071214; DE 60127595 T 20010531; DE 60130658 T 20010531; DE 60140495 T 20010531; DE 60143098 T 20010531; DK 01934447 T 20010531; EP 01934447 A 20010531; EP 05290274 A 20010531; EP 05290275 A 20010531; EP 06076696 A 20010531; ES 01934447 T 20010531; ES 05290274 T 20010531; ES 05290275 T 20010531; ES 06076696 T 20010531; JP 0104586 W 20010531; JP 2001164523 A 20010531; JP 2006140241 A 20060519; JP 2009283084 A 20091214; JP 2009283085 A 20091214; KR 20027016230 A 20010531; KR 20087023872 A 20010531; NO 20025718 A 20021128; NO 20073371 A 20070629; PT 01934447 T 20010531; US 44863406 A 20060607; US 47260306 A 20060622; US 58651509 A 20090923; US 89323807 A 20070815