EP 1744793 A2 20070124 - BIOMIMETIC ORGANIC/INORGANIC COMPOSITES, PROCESSES FOR THEIR PRODUCTION, AND METHODS OF USE
Title (en)
BIOMIMETIC ORGANIC/INORGANIC COMPOSITES, PROCESSES FOR THEIR PRODUCTION, AND METHODS OF USE
Title (de)
BIOMIMETISCHE ORGANISCHE/ANORGANISCHE VERBUNDSTOFFE, VERFAHREN ZU DEREN HERSTELLUNG SOWIE VERWENDUNGSVERFAHREN
Title (fr)
COMPOSITES BIOMIMETIQUES ORGANIQUES/INORGANIQUES ET LEURS PROCEDES DE PRODUCTION ET D'UTILISATION
Publication
Application
Priority
- US 2004033737 W 20041012
- US 69100203 A 20031022
Abstract (en)
[origin: WO2005081699A2] The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.
IPC 8 full level
A61L 27/24 (2006.01); A61L 27/44 (2006.01); A61L 27/46 (2006.01); A61L 31/12 (2006.01); A61L 31/14 (2006.01)
CPC (source: EP)
A61L 27/24 (2013.01); A61L 27/446 (2013.01); A61L 27/46 (2013.01); A61L 31/127 (2013.01); A61L 31/128 (2013.01); A61L 31/146 (2013.01); Y10S 530/811 (2013.01); Y10S 530/812 (2013.01); Y10S 530/813 (2013.01); Y10S 530/814 (2013.01); Y10S 530/815 (2013.01); Y10S 530/817 (2013.01)
Citation (search report)
See references of WO 2005081699A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL HR LT LV MK
DOCDB simple family (publication)
WO 2005081699 A2 20050909; WO 2005081699 A3 20090416; EP 1744793 A2 20070124
DOCDB simple family (application)
US 2004033737 W 20041012; EP 04821537 A 20041012