Global Patent Index - EP 1748805 A1

EP 1748805 A1 20070207 - ABSORBABLE BIOCOMPATIBLE COATINGS

Title (en)

ABSORBABLE BIOCOMPATIBLE COATINGS

Title (de)

RESORBIERBARE BIOKOMPATIBLE BESCHICHTUNGEN

Title (fr)

REVETEMENTS BIOCOMPATIBLES ABSORBABLES

Publication

EP 1748805 A1 20070207 (EN)

Application

EP 05746512 A 20050525

Priority

  • GB 2005002081 W 20050525
  • US 57425004 P 20040525

Abstract (en)

[origin: WO2005115492A1] Biocompatible carrier materials are described herein for enhanced delivery of therapeutic agents. Embodiments include materials and methods for making a biodegradable coating on a surface of a medical device by forming a biodegradable layer on at least a portion of the surface of the medical device, the layer comprising a copolymer and a therapeutic agent releasable into a patient after implantation of the device into the patient, wherein the copolymer is a polyamino acid derivatized to have a hydrophobic hydrocarbon side chain that has a molecular weight from about 14 to about 5000. One embodiment is a polypeptide that includes at least one amino acid that has been modified to include a hydrophobic side chain. The number and type of amino acids and hydrophobic side chains may be altered to adjust the solubility of the material in solvents, and to control the hydrophobic-to-hydrophobic balance of the coatings made with the materials, so as to enhance therapeutic agent delivery. And hydrophilic groups may also be introduced as a further means to adjust the material's property.

IPC 8 full level

A61L 27/22 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01)

CPC (source: EP)

A61L 27/22 (2013.01); A61L 27/227 (2013.01); A61L 27/34 (2013.01); A61L 27/54 (2013.01); A61L 29/048 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61L 31/047 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 2300/416 (2013.01); A61L 2300/604 (2013.01); A61L 2300/606 (2013.01)

C-Set (source: EP)

  1. A61L 27/34 + C08L 77/04
  2. A61L 31/10 + C08L 77/04

Citation (search report)

See references of WO 2005115492A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005115492 A1 20051208; AT 437664 T 20090815; AU 2005247140 A1 20051208; CA 2567194 A1 20051208; CN 1956742 A 20070502; DE 602005015696 D1 20090910; EP 1748805 A1 20070207; EP 1748805 B1 20090729; JP 2008502376 A 20080131; US 2006134166 A1 20060622

DOCDB simple family (application)

GB 2005002081 W 20050525; AT 05746512 T 20050525; AU 2005247140 A 20050525; CA 2567194 A 20050525; CN 200580016808 A 20050525; DE 602005015696 T 20050525; EP 05746512 A 20050525; JP 2007514098 A 20050525; US 13634005 A 20050524