EP 1749093 A2 20070207 - METHOD FOR IDENTIFYING PDE5-MODULATORS
Title (en)
METHOD FOR IDENTIFYING PDE5-MODULATORS
Title (de)
METHODE ZUR IDENTIFIZIERUNG VON PDE5-MODULATOREN
Title (fr)
METHODE D'IDENTIFICATION DE MODULATEURS DE PDE5
Publication
Application
Priority
- EP 2005052269 W 20050518
- DE 102004026717 A 20040528
- DE 102005009671 A 20050228
Abstract (en)
[origin: WO2005116195A2] The invention relates to a novel polypeptide containing the GAFA-domain and GAFB-domain of a human phosphodiesterase 5 (PDE5) and the catalytic domain of an adenylate cyclase, and to the use of this polypeptide in a method for identifying PDE5-modulators.
IPC 8 full level
C12N 9/88 (2006.01); C12N 9/00 (2006.01); C12N 9/16 (2006.01); C12Q 1/44 (2006.01)
CPC (source: EP KR US)
C12N 5/10 (2013.01 - KR); C12N 9/16 (2013.01 - EP US); C12N 9/88 (2013.01 - EP KR US); C12N 15/52 (2013.01 - KR); C12N 15/62 (2013.01 - KR); C12Q 1/44 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); G01N 2500/04 (2013.01 - EP US)
Citation (search report)
See references of WO 2005116195A2
Citation (examination)
- MARTINEZ ET AL: "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding", PNAS, vol. 99, no. 20, 1 October 2002 (2002-10-01), pages 13260 - 13265, XP002323965
- ZORAGHI ET AL: "Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins", MOLECULAR PHARMACOLOGY, vol. 65, no. 2, 2004, pages 267 - 276
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005116195 A2 20051208; WO 2005116195 A3 20060216; AU 2005248079 A1 20051208; CA 2590553 A1 20051208; EP 1749093 A2 20070207; IL 179057 A0 20070308; JP 2008500824 A 20080117; KR 20070030221 A 20070315; NO 20065850 L 20061218; NZ 551240 A 20090828; US 2009087871 A1 20090402
DOCDB simple family (application)
EP 2005052269 W 20050518; AU 2005248079 A 20050518; CA 2590553 A 20050518; EP 05743032 A 20050518; IL 17905706 A 20061106; JP 2007513912 A 20050518; KR 20067026712 A 20061219; NO 20065850 A 20061218; NZ 55124005 A 20050518; US 59699005 A 20050518