Global Patent Index - EP 1749829 A1

EP 1749829 A1 20070207 - JNK inhibitors

Title (en)

JNK inhibitors

Title (de)

JNK Inhibitoren

Title (fr)

JNk inhibiteurs

Publication

EP 1749829 A1 20070207 (EN)

Application

EP 06254089 A 20060803

Priority

GB 0516156 A 20050805

Abstract (en)

The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.

IPC 8 full level

C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61P 25/28 (2006.01)

CPC (source: EP US)

A61P 25/28 (2018.01 - EP); C07D 471/04 (2013.01 - EP US)

Citation (applicant)

  • WO 2004078757 A2 20040916 - EISAI LONDON RES LAB LTD [GB], et al
  • WO 2004078756 A2 20040916 - EISAI LONDON RES LAB LTD [GB], et al
  • WO 2004078756 A2 20040916 - EISAI LONDON RES LAB LTD [GB], et al
  • WO 2004101565 A2 20041125 - EISAI LONDON RES LAB LTD [GB], et al
  • WO 03082868 A1 20031009 - EISAI LONDON RES LAB LTD [GB], et al
  • EP 0636626 A1 19950201 - GLAXO LAB SA [FR]
  • WO 2005085244 A1 20050915 - EISAI LONDON RES LAB LTD [GB], et al
  • MIGITA, BULL. CHEM. SOC. JPN, vol. 53, 1980, pages 1385
  • KONDO; MITSUDO, CHEM. REV., vol. 100, 2000, pages 3205
  • BOCCHI; PALLA, SYNTHESIS, 1982, pages 1096
  • DENG, SYNLETT, vol. 7, 2004, pages 1254
  • HERRADURA, ORG. LETT., vol. 2, 2000, pages 2019
  • SIMON, J. ORG. CHEM., vol. 66, 2001, pages 633
  • ENGLER, J. ORG. CHEM., vol. 61, 1996, pages 9297
  • LARRAYA, EUR. J. MED. CHEM., vol. 39, 2004, pages 515
  • VIAUDE, TETRAHEDRON, vol. 53, 1997, pages 5159
  • ZOU, TETRAHEDRON LETT., vol. 42, 2001, pages 7213
  • QUACH; BATEY, ORG. LETT., vol. 5, 2003, pages 4397
  • CHAN, TETRAHEDRON LETT., vol. 44, 2003, pages 3863
  • WOLFE, ACC CHEM RES, vol. 31, 1998, pages 805
  • ZIM; BUCHWALD, ORG. LETT., vol. 5, 2003, pages 24 13
  • LANG, TETRAHEDRON LETT., vol. 42, 2001, pages 3251
  • SHIOIRI, J. AM. CHEM. SOC., vol. 94, 1972, pages 6203
  • ANQUETIN, BIOORG. MED CHEM. LETT., vol. 14, 2004, pages 2773
  • KAPFERER; VASELLA, HELV. CHIM. ACTA, vol. 87, 2004, pages 2764
  • LI, J. ORG. CHEM., vol. 67, 2002, pages 5394 - 5397
  • "BORONIC ACIDS. PREPARATION AND APPLICATIONS IN ORGANIC SYNTHESIS AND MEDICINE", 2005, WILEY VCH
  • RENAUD; OUELLET, J. AM. CHEM. SOC., vol. 120, 1998, pages 7995
  • PEREYRE: "TIN IN ORGANIC SYNTHESIS", 1987, BUTTERWORTH
  • LEE; DAI, TETRAHEDRON, vol. 53, 1997, pages 859
  • SMITH, CHEM. REV., vol. 100, 2000, pages 3257
  • EVANS, J. AM. CHEM. SOC., vol. 120, 1998, pages 5921
  • DENMARK; CHOI, J. AM. CHEM. SOC., vol. 121, 1999, pages 5821
  • SUZUKI, PURE APPL. CHEM., vol. 63, 1991, pages 419
  • J. AM. CHEM. SOC., vol. 122, 2000, pages 4020
  • STILLE, ANGEW. CHEM. , INT.ED, ENGL., vol. 25, 1986, pages 508
  • MITCHELL, SYNTHESIS, vol. 803, 1992
  • LITTKE, J. AM. CHEM. SOC., vol. 124, 2002, pages 6343
  • HATANAKA, J. ORG. CHEM., vol. 53, 1988, pages 918
  • HATANAKA, SYNLETT, vol. 845, 1991
  • TAMAO, TETRAHEDRON LETT., vol. 30, 1989, pages 6051
  • DENMARK, ORG. LETT., vol. 2, 2000, pages 565
  • SCHRÖTER, TETRAHEDRON, vol. 61, 2005, pages 224 5
  • HASSAN, CHEM. REV., vol. 102, 2002, pages 1359
  • COMINS; DEHGHANI, TETRAHEDRON LETTERS, vol. 33, 1992, pages 6299
  • ALVAREZ, SYNTHESIS, vol. 4, 1999, pages 615
  • AMAT, J. ORG. CHEM., vol. 59, 1994, pages 10
  • HODSON, TETRAHEDRON, vol. 50, 1994, pages 1899
  • KAWASAKI, J. CHEM. SOC. CHEM. COMMUN., vol. 18, 1994, pages 2085
  • CLARIDGE, TETRAHEDRON, vol. 53, 1997, pages 4035
  • FONQUERNA, BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 1165
  • HEATH-BROWN; PHILPOTT, J. CHEM. SOC., 1965, pages 7165
  • MACOR; RYAN, HETEROCYCLES, vol. 31, 1990, pages 1497
  • KOTSUKI, J. ORG. CHEM., vol. 61, 1996, pages 984
  • GILCHRIST, J. CHEM. SOC. PERKIN TRANS, vol. 1, 2001, pages 2491
  • HAUBMANN, BIOORG. MED. CHEM. LETT., vol. 9, 1999, pages 3143
  • NIELSON, D. G.: "THE CHEMISTRY OF AMIDINES AND IMIDATES", 1975, JOHN WILEY AND SONS, pages: 443
  • FRANCHETTI, BIOORG. MED. CHEM. LETT., vol. 11, 2001, pages 6 7
  • LI, ORG. SYNTH., vol. 81, 2004, pages 105
  • BOERÉ, J. ORGANOMET. CHEM., vol. 331, 1987, pages 161
  • THURKAUF, J. MED. CHEM., vol. 38, 1995, pages 2251
  • GAUDRY; MARQUET, ORG. SYNTH., vol. VI, 1988, pages 193
  • JAVED; KAHLON, J. HETEROCYCL. CHEM., vol. 39, 2002, pages 627
  • ZAIDLEWICZ, HETEROCYCLES, vol. 55, 2001, pages 569
  • GU, BIOORG. MED. CHEM. LETT., vol. 9, 1999, pages 569
  • JEREB, SYNTHESIS, vol. 6, 2003, pages 8 53
  • LEE; JIN, SYNTH. COMMUN., vol. 29, 1999, pages 2769
  • BEKAERT, TETRAHEDRON LETT., vol. 41, 2000, pages 2903
  • LOPEZ, FARMACO, vol. 55, 2000, pages 40
  • DUBAC, SYNTH. COMMUN., vol. 21, 1991, pages 11
  • OLAH, J. ORG. CHEM., vol. 49, 1984, pages 2032
  • DENMARK; DAPPER, J. ORG. CHEM., vol. 49, 1984, pages 798
  • ITO, J. ORG. CHEM., vol. 45, 1980, pages 2022
  • SHIBATA, BULL. CHEM. SOC. JPN., vol. 64, 1991, pages 3749
  • KROHN, J. PRAKT. CHEM., vol. 341, 1999, pages 62
  • BLANCO, SYNTHESIS, 1976, pages 194
  • BALDWIN, J. ORG. CHEM., vol. 66, 2001, pages 2588
  • PAQUETTE, TETRAHEDRON LETT., vol. 26, 1985, pages 1611
  • SHA, J. ORG. CHEM., vol. 52, 1987, pages 3919
  • AIZPURUA, TETRAHEDRON, vol. 41, 1985, pages 2903
  • SCETTRI, SYNTH. COMMUN., vol. 12, 1982, pages 11 270
  • RUBOTTOM; MOTT, J. ORG. CHEM., vol. 44, 1979, pages 1731
  • DALLA CORT, J. ORG. CHEM., vol. 56, 1991, pages 6708
  • VANKAR; KUMARAVEL, TETRAHEDRON LETT., vol. 25, 1984, pages 233
  • KRAUS, J. ORG. CHEM., vol. 55, 1990, pages 1624
  • CHENEY; PAQUETTE, J. ORG. CHEM., vol. 54, 1989, pages 3334
  • MOLINA, TETRAHEDRON LETT., vol. 43, 2002, pages 1005
  • YEUNG, TETRAHEDRON LETT., vol. 43, 2002, pages 5793
  • SHOJI, CHEM. PHARM. BULL., vol. 21, 1973, pages 2639
  • BENDAAS, J. HETEROCYCL. CHEM., vol. 36, 1999, pages 1291
  • TIMMERMANS, J. HETEROCYCL. CHEM., vol. 9, 1972, pages 1373
  • KUMARI, INDIAN J. CHEM., SECT. B, vol. 35, 1996, pages 846
  • SAMANTA, J. CHEM. RES., SYNOP., vol. 11, 1995, pages 4 29
  • INDIAN J. CHEM., SECT B. : ORG. CHEM. INCL. MED. CHEM., vol. 32, 1993, pages 1288
  • WILLETTE, ADV. HETEROCYCL. CHEM., vol. 9, 1968, pages 27
  • PAILER, MONATSH. CHEM., vol. 110, 1979, pages 589
  • BROWN; KERR, TETRAHEDRON LETT., vol. 42, 2001, pages 983
  • GRIBBLE; CONWAY, SYNTH. COMMUN., vol. 22, 1992, pages 2129
  • SPEAKE, BIOORG. MED. CHEM. LETT., vol. 13, 2003, pages 1183
  • HIREMATH, INDIAN J. CHEM., SECT. B, vol. 19, 1980, pages 767
  • HERBERT; WIBBERLEY, J. CHEM. SOC. C, 1969, pages 1505
  • KELLY; LANG, J. ORG. CHEM., vol. 61, 1996, pages 4623
  • BANSAL, INDIAN J. CHEM., SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 39, 2000, pages 357
  • MOLINA, SYNTHESIS, 1993, pages 54
  • DHAR, BIOORG. MED. CHEM. LETT., vol. 12, 2002, pages 3 305
  • DOYLE; MOODY, SYNTHESIS, 1994, pages 1021
  • MOODY, J. CHEM. SOC., PERKIN TRANS., vol. 1, 1997, pages 2413
  • OIKAWA, HETEROCYCLES, vol. 12, 1979, pages 14 57
  • NISHIDA, TETRAHEDRON LETT., vol. 39, 1998, pages 5983
  • HAUBMANN, BIOORG. MED. CHEM. LETT., vol. 9, 1999, pages 31 43
  • VEDEJS; BARDA, ORG. LETT., vol. 2, 2000, pages 1033
  • ROEDER; PIGULLA, ARCH PHARM (WEINHEIM, GER, vol. 311, 1978, pages 817
  • HASAN, J. PRAKT. CHEM., vol. 332, 1990, pages 666
  • KIDWAI; SAPRA, ORG. PREP. PROCED. INT., vol. 33, 2001, pages 381
  • BARUAH, HETEROCYCLES, vol. 27, 1988, pages 1127
  • JEDLOVSKA, COLLECT. CZECH . CHEM. COMMUN., vol. 55, 1990, pages 2481
  • CORY, HELV. CHIM. ACTA, vol. 60, 1977, pages 2294
  • BEN-BASSET, J. MED. CHEM., vol. 19, 1976, pages 928
  • HASSNER; ALEXANIAN, J. ORG. CHEM., vol. 44, pages 3861
  • SHORT; ZIEGLER, TETRAHEDRON LETT., vol. 34, 1993, pages 75
  • SPR Y; BHALA, HETEROCYCLES, vol. 24, 1986, pages 1799
  • EL-TAWEEL; ELNAGDI, J. HETEROCYCL. CHEM., vol. 38, 2001, pages 981
  • SCHWARZ, ORG. SYNTH., vol. III, 1955, pages 332
  • THOMPSON, BIOORG. MED. CHEM. LETT., vol. 4, 1994, pages 24 41
  • BHATTACHARYA, J. CHEM. SOC., PERKIN TRANS., vol. I, 1995, pages 1543
  • KRAWCZYK, J. MED. CHEM., vol. 38, 1995, pages 4115
  • GU, BIOORG. MED. CHEM. LETT., vol. 9, 1999, pages 5 69
  • MANAKA; SATO, SYNTH. COMMUN., vol. 35, 2005, pages 761
  • LIN, SYNTHESIS, 1992, pages 1219
  • QIAO, ORG. LETT., vol. 3, 2001, pages 3655
  • ZAWISTOSKI, J. HETEROCYCL. CHEM., vol. 27, 1990, pages 519
  • DI FABIO; PENTASSUGLIA, SYNTH. COMMUN., vol. 28, 1998, pages 51
  • H AYASHI, HETEROCYCLES, vol. 51, 1999, pages 1233
  • ARYA, INDIAN J. CHEM., SECT. B, vol. 15, 1977, pages 473
  • SALEH, NUCLEOSIDES, NUCLEOTIDES NUCLEIC ACIDS, vol. 21, 2002, pages 401
  • JIANG; GU, HETEROCYCLES, vol. 53, 2000, pages 1559
  • KELAREV, KHIM. GETEROTSIKL. SOEDIN., 1993, pages 189
  • OMODEI-SALE, J. MED. CHEM., vol. 26, 1983, pages 1187
  • MCKILLOP, TETRAHEDRON LETT., vol. 23, 1982, pages 3357
  • HUNTER; NEILSON, J. CHEM. SOC. PERKIN TRANS. 1: ORG. BIO-ORG. CHEM., 1988, pages 1439
  • ROSTAMIZADEH, SYNTH. COMMUN., vol. 33, 2003, pages 113
  • DUMAITRE; DODIC, EUR. PAT. APPL., 1995
  • VANEK, COLLECT. CZECH . CHEM. COMMUN., vol. 49, 1984, pages 2492
  • GAUTUN; CARLSEN, MOLECULES, vol. 6, 2001, pages 9 69
  • WHITFIELD; PAPADOPOULOS, SYNTHESIS, 1985, pages 423
  • WHITFIELD; PAPADOPOULOS, J. HETEROCYCLIC CHEM., vol. 18, 1981, pages 1197
  • SACZEWSKI; FOKS, SYNTHESIS, 1986, pages 751
  • OKAJIMA; OKADA, J. HETEROCYCLIC CHEM., vol. 28, 1991, pages 177
  • CHEN, BIOORG. MED. CHEM. LETT., vol. 11, 2001, pages 31 65
  • BUSCEMI, J. ORG. CHEM., vol. 68, 2003, pages 605 - 608
  • AKBARZADEH, BIOORG. MED. CHEM., vol. 11, 2003, pages 7 69
  • SWAIN, J. MED. CHEM., vol. 34, 1991, pages 140
  • SHVEKHGEIMER, KHIM. GETEROTSIKL. SOEDIN., 1984, pages 1609
  • CORSARO, J. CHEM. RES. SYNOP., 1989, pages 246
  • RAJAGOPALAN; ADVANI, J. ORG. CHEM., vol. 30, 1965, pages 3369
  • KOCEVAR, SYNTH. COMMUN., vol. 18, 1988, pages 1427
  • BEDFORD, J. MED. CHEM., vol. 29, 1986, pages 2174
  • PEAKE; STRICKLAND, SYNTH. COMMUN., vol. 16, 1986, pages 763
  • IWAKURA, BULL. CHEM. SOC. JPN., vol. 41, 1968, pages 2954
  • KELAREV, CHEM. HETEROCYCL. COMP. (NEW YORK, vol. 36, 2000, pages 207
  • KOVALENKO, MOLECULES, vol. 5, 2000, pages 1146
  • MONGE VEGA, BOL. SOC. QUIM. PERU, vol. 49, 1983, pages 120
  • HIREMATH, INDIAN J. CHEM., SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 19B, 1980, pages 1031
  • REYNAUD, J. HETEROCYCL. CHEM., vol. 29, 1992, pages 991
  • TABOADA, J. CARBOHYD. CHEM., vol. 23, 2004, pages 325
  • BRATUSEK, ARKIVOC, vol. 5, 2003, pages 77
  • EL-TAWEEL, J. HETEROCYCL. CHEM., vol. 38, 2001, pages 981
  • WESTMAN; LUNDIN, SYNTHESIS, 2003, pages 1025
  • CHHABRIA; SHISHOO, HETEROCYCLES, vol. 51, 1999, pages 2723
  • ENGUEHARD, J. ORG. CHEM, vol. 68, 2003, pages 5614
  • CRISTAU, EUR. J. ORG. CHEM., 2004, pages 695

Citation (search report)

  • [Y] WO 2004078756 A2 20040916 - EISAI LONDON RES LAB LTD [GB], et al
  • [Y] WO 03082869 A1 20031009 - EISAI LONDON RES LAB LIMTED [GB], et al
  • [Y] WO 0210137 A2 20020207 - SIGNAL PHARM INC [US], et al
  • [Y] RESNICK L ET AL: "Targeting JNK3 for the treatment of neurodegenerative disorders", DDT - DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 9, no. 21, 1 November 2004 (2004-11-01), pages 932 - 939, XP004610030, ISSN: 1359-6446

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

EP 1749829 A1 20070207; EP 1749829 B1 20101103; AT E486870 T1 20101115; DE 602006017930 D1 20101216; ES 2355738 T3 20110330; GB 0516156 D0 20050914; US 2007072896 A1 20070329; US 2010035878 A1 20100211; US 7645769 B2 20100112

DOCDB simple family (application)

EP 06254089 A 20060803; AT 06254089 T 20060803; DE 602006017930 T 20060803; ES 06254089 T 20060803; GB 0516156 A 20050805; US 49933406 A 20060804; US 57395009 A 20091006