EP 1753409 A2 20070221 - DOSAGE FORM CONTAINING THE ACTIVE INGREDIENT CHOLYLSARCOSINE
Title (en)
DOSAGE FORM CONTAINING THE ACTIVE INGREDIENT CHOLYLSARCOSINE
Title (de)
ARZNEIFORM, ENTHALTEND DEN WIRKSTOFF CHOLYLSARCOSIN
Title (fr)
FORME POSOLOGIQUE CONTENANT L'AGENT ACTIF CHOLYLSARCOSINE
Publication
Application
Priority
- EP 2005005157 W 20050512
- DE 102004027924 A 20040609
Abstract (en)
[origin: WO2005120467A2] The invention relates to a dosage form, containing the active ingredient cholylsarcosine, in the form of pellets, which are provided with a polymer coating that is resistant to gastric juices. The invention is characterised in that it discloses pellets comprising an active ingredient, which contain between 50 and 80 wt. % of the active ingredient cholylsarcosine and between 50 and 20 wt. % of one or more conventional pharmaceutical adjuvants as binding agents, whereby at least 90 wt. % of said adjuvants are water-soluble and the size of at least 80 % of the pellets comprising an active ingredient is between 800 and 2,500 mu m. The granulates containing an active ingredient are coated with an anionic, film-forming polymer coating agent, which dissolves in a 0.07M sodium phosphate buffer with a pH value of 5.5 at a dissolution rate of at least 10 mg/min*g and whose dissolution rate in a 0.07M sodium phosphate buffer with a pH value of 6.0 is at least 200 mg/min*g. The polymer coating amounts to between 5 and 15 wt. % of the pellet weight. The invention also relates to a method for producing said dosage form.
IPC 8 full level
A61K 9/50 (2006.01); A61K 31/575 (2006.01); A61K 38/00 (2006.01); A61P 1/16 (2006.01)
CPC (source: EP US)
A61K 9/5026 (2013.01 - EP US); A61K 31/575 (2013.01 - EP US); A61P 1/14 (2017.12 - EP); A61P 1/16 (2017.12 - EP)
Citation (search report)
See references of WO 2005120467A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005120467 A2 20051222; WO 2005120467 A3 20060608; CA 2567063 A1 20051222; CN 1956709 A 20070502; DE 102004027924 A1 20051229; EP 1753409 A2 20070221; JP 2008501736 A 20080124; MX PA06013368 A 20070123; US 2007243247 A1 20071018
DOCDB simple family (application)
EP 2005005157 W 20050512; CA 2567063 A 20050512; CN 200580016162 A 20050512; DE 102004027924 A 20040609; EP 05741705 A 20050512; JP 2007526227 A 20050512; MX PA06013368 A 20050512; US 56958105 A 20050512