EP 1753717 A1 20070221 - METHOD FOR PRODUCING DIPHENYL AZETIDINONE DERIVATIVES
Title (en)
METHOD FOR PRODUCING DIPHENYL AZETIDINONE DERIVATIVES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON DIPHENYL-AZETIDINON-DERIVATEN
Title (fr)
PRODEDE DE PRODUCTION DE DERIVES DE DIPHENYLAZETIDINONE
Publication
Application
Priority
- EP 2005005497 W 20050520
- DE 102004025072 A 20040521
Abstract (en)
[origin: WO2005113495A1] The invention relates to a method for producing diphenyl azetidinone derivatives of general formula (I) or forms protected in the substituents X, R<1> and/or R<2>, wherein the symbols, substituents, and indices have the following designations: X = H, OH; R<l> = OH, OCH3; R<2> = F, CH2CH3, CH2NHR<4>; R<3> = H, F; R<4> = H, CO-(CH2-)nCO-R<5>, CO-(CH2-)nNHR<6>; n = whole numbers from 4 to 16; R<5> = OH, NH-CH2-[CH(OH)-]mCH2OH; R<6> = H, CO-[CH(OH)-]mCH2OH; and m = whole numbers from 1 to 5. According to said method, novel compounds of general formula (II), wherein Y = H, H; H, OH; H, OAc; H, OSi(alkyl)o(aryl)p where o, p = 0, 1, 2 or 3 and o + p = 3; H, OTHP; H, OC(Aryl)3; H, OCH2OAlkyl; H, OCH(OAlkyl)CH3; H, OAlkyl; H, OCH2aryl; Oalkyl, Oalkyl; and cyclic ketone acetyl such as O-(CH2-)q-O where q = 2 or 3, are reacted with imines of general formula (III) wherein R<7> = R<1> and O protective groups and R<8> = e.g. R<2>.
IPC 8 full level
C07C 233/20 (2006.01); C07C 235/34 (2006.01); C07C 237/20 (2006.01); C07D 205/08 (2006.01); C07F 7/02 (2006.01)
CPC (source: EP US)
A61P 3/06 (2017.12 - EP); A61P 9/10 (2017.12 - EP); C07D 205/08 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Citation (search report)
See references of WO 2005113495A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005113495 A1 20051201; AR 049283 A1 20060712; AU 2005245123 A1 20051201; CA 2567481 A1 20051201; CN 100582092 C 20100120; CN 1956951 A 20070502; DE 102004025072 A1 20051215; EP 1753717 A1 20070221; IL 178993 A0 20070308; JP 2007538041 A 20071227; MX PA06013258 A 20070228; TW 200611895 A 20060416; US 2007149501 A1 20070628; US 7563888 B2 20090721; UY 28913 A1 20051230
DOCDB simple family (application)
EP 2005005497 W 20050520; AR P050102100 A 20050520; AU 2005245123 A 20050520; CA 2567481 A 20050520; CN 200580016190 A 20050520; DE 102004025072 A 20040521; EP 05743217 A 20050520; IL 17899306 A 20061101; JP 2007517093 A 20050520; MX PA06013258 A 20050520; TW 94116388 A 20050520; US 55731006 A 20061107; UY 28913 A 20050520