Global Patent Index - EP 1754480 A3

EP 1754480 A3 20070509 - Compositions comprising phospholipase c inhibitors and methods for enhancing paracellular permeability across epithelial and endothelial barriers

Title (en)

Compositions comprising phospholipase c inhibitors and methods for enhancing paracellular permeability across epithelial and endothelial barriers

Title (de)

Zusammensetzungen, die Phospholipase C Inhibitoren enthalten und Verfahren zur Erhöhung parazellulärer Permeabilität der Epithelbarriere und Endothelbarriere

Title (fr)

Compositions et méthodes permettant d'améliorer la perméabilité paracellulaires des barrières épitheliales et endotheliales

Publication

EP 1754480 A3 20070509 (EN)

Application

EP 06119516 A 20011010

Priority

  • EP 01986603 A 20011010
  • US 23932800 P 20001010

Abstract (en)

[origin: WO0230408A2] Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permaeability in the subject at the the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.

IPC 8 full level

A61K 31/37 (2006.01); A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/353 (2006.01); A61K 31/56 (2006.01); A61K 31/58 (2006.01); A61K 31/661 (2006.01); A61K 31/685 (2006.01); A61K 45/06 (2006.01); A61K 47/22 (2006.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); A61P 1/14 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP US)

A61K 31/353 (2013.01 - EP US); A61K 31/37 (2013.01 - EP US); A61K 31/58 (2013.01 - EP US); A61K 31/685 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 1/14 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

Citation (search report)

  • [X] WO 9810776 A1 19980319 - SHANAHAN PRENDERGAST ELIZABETH [IE]
  • [X] CEREIJIDO M ET AL: "The making of a tight junction.", JOURNAL OF CELL SCIENCE, no. SUPPL. 17, 1993, pages 127 - 132, XP008014962, ISSN: 0021-9533
  • [X] HASHIMOTO KEI ET AL: "Effects of beta-lactoglobulin on the tight-junctional stability of Caco-2-SF monolayer.", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 62, no. 9, 1998, pages 1819 - 1821, XP001109786, ISSN: 0916-8451
  • [X] PERRELLA FRANK W ET AL: "Phospholipase C inhibitors: A new class of cytotoxic agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 14, 1994, pages 2232 - 2237, XP002413644, ISSN: 0022-2623
  • [X] LIN T ET AL: "Influence of insecticide exposure on the in vivo and in vitro metabolic activity of rats", ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 1974, vol. 2, no. 4, 1974, pages 364 - 377, XP008073274
  • [T] WARD PETER D ET AL: "Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 38, 20 September 2002 (2002-09-20), September 20, 2002, pages 35760 - 35765, XP001149324, ISSN: 0021-9258
  • [A] CEREIJIDO M ET AL: "Molecular Physiology and Pathophysiology of Tight Junctions: I. Biogenesis of tight junctions and epithelial polarity.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 279, no. 3 Part 1 of 2, September 2000 (2000-09-01), pages G477 - G482, XP001031292, ISSN: 0002-9513
  • [A] GASBARRINI G ET AL: "Structure and function of tight junctions. Role in intestinal barrier.", ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 31, no. 6, August 1999 (1999-08-01), pages 481 - 488, XP008014922, ISSN: 1125-8055

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

Designated extension state (EPC)

AL LT LV MK RO SI

DOCDB simple family (publication)

WO 0230408 A2 20020418; WO 0230408 A3 20031106; AT E348622 T1 20070115; AT E496619 T1 20110215; AU 2435402 A 20020422; CA 2425215 A1 20020418; CA 2425215 C 20091229; DE 60125420 D1 20070201; DE 60125420 T2 20070927; DE 60143975 D1 20110310; DK 1379235 T3 20070129; DK 1754480 T3 20110516; EP 1379235 A2 20040114; EP 1379235 B1 20061220; EP 1754480 A2 20070221; EP 1754480 A3 20070509; EP 1754480 B1 20110126; ES 2276847 T3 20070701; JP 2004532795 A 20041028; MX PA03002934 A 20040504; US 2002115641 A1 20020822; US 7713949 B2 20100511

DOCDB simple family (application)

US 0131501 W 20011010; AT 01986603 T 20011010; AT 06119516 T 20011010; AU 2435402 A 20011010; CA 2425215 A 20011010; DE 60125420 T 20011010; DE 60143975 T 20011010; DK 01986603 T 20011010; DK 06119516 T 20011010; EP 01986603 A 20011010; EP 06119516 A 20011010; ES 01986603 T 20011010; JP 2002533851 A 20011010; MX PA03002934 A 20011010; US 97451901 A 20011010