EP 1758594 A1 20070307 - COMBINATION FOR INHIBITING BONE RESORPTION COMPRISING A BISPHOSPONATE (ALENDRONA) AND A VITAMIN D (CHOLECALCIFEROL)
Title (en)
COMBINATION FOR INHIBITING BONE RESORPTION COMPRISING A BISPHOSPONATE (ALENDRONA) AND A VITAMIN D (CHOLECALCIFEROL)
Title (de)
KOMBINATION ZUR HEMMUNG DER KNOCHENRESORPTION AUS EINEM BISPHOSPHONAT (ALENDRONAT) UND EINEM VITAMIN D (CHOLECALIFEROL)
Title (fr)
COMBINAISON POUR INHIBER LA RESORPTION OSSEUSE COMPRENANT UN BISPHOSPONATE (ALENDRONATE) ET UNE VITAMINE D (CHOLECALCIFEROL)
Publication
Application
Priority
US 2004015743 W 20040519
Abstract (en)
[origin: WO2005117906A1] Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D3 suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.
IPC 8 full level
A61K 31/663 (2006.01); A61K 31/69 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); G01N 33/82 (2006.01)
CPC (source: EP)
A61K 31/59 (2013.01); A61K 31/593 (2013.01); A61K 31/663 (2013.01); A61K 31/69 (2013.01); A61P 19/02 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 2005117906A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
LV
DOCDB simple family (publication)
WO 2005117906 A1 20051215; BR PI0418756 A 20070911; CN 1993134 A 20070704; EP 1758594 A1 20070307
DOCDB simple family (application)
US 2004015743 W 20040519; BR PI0418756 A 20040519; CN 200480043618 A 20040519; EP 04776045 A 20040519