Global Patent Index - EP 1759701 A3

EP 1759701 A3 20070314 - Buproprion Metabolites and Methods of Their Synthesis and Use.

Title (en)

Buproprion Metabolites and Methods of Their Synthesis and Use.

Title (de)

Bupropinmetaboliten und deren Synthese und Verwendung

Title (fr)

Métabolites du bupropion et leur synthèse et utilisation

Publication

EP 1759701 A3 20070314 (EN)

Application

EP 06120882 A 20000229

Priority

  • EP 00913649 A 20000229
  • US 12227799 P 19990301
  • US 14832499 P 19990811
  • US 51024100 A 20000222

Abstract (en)

[origin: WO0051546A2] Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affective disorders, cerebral function disorders, cigarette smoking, and incontinence. The invention further discloses methods of making optically pure bupropion metabolites.

IPC 8 full level

A61K 31/133 (2006.01); A61K 31/5375 (2006.01); A61K 31/00 (2006.01); A61K 31/135 (2006.01); A61K 31/137 (2006.01); A61K 31/165 (2006.01); A61K 31/415 (2006.01); A61K 31/4178 (2006.01); A61K 31/43 (2006.01); A61K 31/435 (2006.01); A61K 31/4375 (2006.01); A61K 31/439 (2006.01); A61K 31/4427 (2006.01); A61K 31/46 (2006.01); A61K 31/465 (2006.01); A61K 31/50 (2006.01); A61K 31/53 (2006.01); A61K 31/535 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61P 13/10 (2006.01); A61P 15/10 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/16 (2006.01); A61P 25/20 (2006.01); A61P 25/24 (2006.01); A61P 25/34 (2006.01); A61P 43/00 (2006.01); C07C 45/51 (2006.01); C07C 45/63 (2006.01); C07C 49/76 (2006.01); C07C 49/807 (2006.01); C07C 49/82 (2006.01); C07C 49/84 (2006.01); C07C 213/00 (2006.01); C07C 215/30 (2006.01); C07C 225/16 (2006.01); C07C 317/14 (2006.01); C07D 265/32 (2006.01)

CPC (source: EP US)

A61K 31/00 (2013.01 - EP US); A61K 31/135 (2013.01 - EP US); A61K 31/137 (2013.01 - EP US); A61K 31/165 (2013.01 - EP US); A61K 31/415 (2013.01 - EP US); A61K 31/43 (2013.01 - EP US); A61K 31/435 (2013.01 - EP US); A61K 31/46 (2013.01 - EP US); A61K 31/465 (2013.01 - EP US); A61K 31/50 (2013.01 - EP US); A61K 31/53 (2013.01 - EP US); A61K 31/535 (2013.01 - EP US); A61K 31/5375 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 13/10 (2017.12 - EP); A61P 15/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/34 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 45/511 (2013.01 - EP US); C07C 45/63 (2013.01 - EP US); C07C 49/84 (2013.01 - EP US); C07D 265/32 (2013.01 - EP US); C07B 2200/07 (2013.01 - EP US)

Citation (search report)

  • [PX] WO 9937305 A1 19990729 - GLAXO GROUP LTD [GB], et al
  • [A] MUSSO ET AL: "Synthesis and evaluation of the antidepressant activity of the enentiomers of bupropion", CHIRALITY, WILEY-LISS, NEW YORK, US, vol. 5, no. 7, 1993, pages 495 - 500, XP002107656, ISSN: 0899-0042
  • [Y] KELLEY JAMES L ET AL: "-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: A novel antidepressant agent and selective inhibitor of norepinephrine uptake", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 2, 1996, pages 347 - 349, XP002164358, ISSN: 0022-2623
  • [XY] SNYDER A M ET AL: "STRESS-INDUCED NEUROLOGICAL IMPAIRMENTS IN AN ANIMAL MODEL OF PARKINSONISM", ANNALS OF NEUROLOGY, BOSTON, US, vol. 18, no. 5, November 1985 (1985-11-01), pages 544 - 551, XP008070507, ISSN: 0364-5134
  • [XY] MCNULTY M ET AL: "ANTICONVULSANT AND PROCONVULSANT EFFECTS OF BUPROPION AND FENCAMFAMIN IN THE GENETICALLY EPILEPSY-PRONE RAT", FEDERATION PROCEEDINGS, vol. 44, no. 4, 1985, & 69TH ANNUAL MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, ANAHEIM, CALIF, pages 1107, XP008070452, ISSN: 0014-9446
  • [XY] GOETZ C G ET AL: "BUPROPION IN PARKINSONS DISEASE", NEUROLOGY, vol. 34, no. 8, 1984, pages 1092 - 1094, XP008070505, ISSN: 0028-3878
  • [X] HANSARD M J ET AL: "The antiparkinsonian ability of bupropion in MPTP-treated common marmosets", BRITISH JOURNAL OF PHARMACOLOGY, vol. 125, no. PROC. SUPPL., December 1998 (1998-12-01), & JOINT MEETING OF THE BRITISH PHARMACOLOGICAL SOCIETY AND THE PHYSIOLOGICAL SOCIETY; SOUTHAMPTON, ENGLAND, UK; SEPTEMBER 8-11, 1998, pages 66P, XP008070506, ISSN: 0007-1188
  • [X] MUSSO D L ET AL: "Synthesis and evaluation of the anticonvulsant activity of a series of 2-amino-1-phenyl-1-propanols derived from the metabolites of the antidepressant bupropion", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 1, 7 January 1997 (1997-01-07), pages 1 - 6, XP004135955, ISSN: 0960-894X
  • [Y] "Practice guideline for the greatment of patients with Alzheimer's disease and other dementias of late life", AMERICAN JOURNAL OF PSYCHIATRY 1997 UNITED STATES, vol. 154, no. 5 SUPPL., 1997, pages 1 - 39, XP008070457, ISSN: 0002-953X
  • [Y] TUNE L E: "Depression and Alzheimer's disease", DEPRESSION AND ANXIETY 1998 UNITED STATES, vol. 8, no. SUPPL. 1, 1998, pages 91 - 95, XP008070454, ISSN: 1091-4269
  • [PA] SHRETHRA M ET AL: "Status epilepticus secondary to bupropion overdose", JOURNAL OF TOXICOLOGY CLINICAL TOXICOLOGY, vol. 37, no. 5, August 1999 (1999-08-01), & ANNUAL MEETING OF THE NORTH AMERICAN CONGRESS OF CLINICAL TOXICOLOGY; LA JOLLA, CALIFORNIA, USA; SEPTEMBER 28-OCTOBER 4, 1999, pages 634 - 635, XP008070453, ISSN: 0731-3810

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

WO 0051546 A2 20000908; WO 0051546 A3 20010111; AT E492279 T1 20110115; AU 3505500 A 20000921; AU 775642 B2 20040812; CA 2362361 A1 20000908; DE 60045427 D1 20110203; EP 1165086 A2 20020102; EP 1165086 A4 20060208; EP 1759701 A2 20070307; EP 1759701 A3 20070314; EP 1759701 B1 20101222; JP 2004513061 A 20040430; JP 4664505 B2 20110406; US 2002052340 A1 20020502; US 6342496 B1 20020129

DOCDB simple family (application)

US 0005109 W 20000229; AT 06120882 T 20000229; AU 3505500 A 20000229; CA 2362361 A 20000229; DE 60045427 T 20000229; EP 00913649 A 20000229; EP 06120882 A 20000229; JP 2000602018 A 20000229; US 51024100 A 20000222; US 98793001 A 20011116