EP 1764413 A1 20070321 - PROTEIN PREPARATION CONTAINING S1-5
Title (en)
PROTEIN PREPARATION CONTAINING S1-5
Title (de)
PROTEINVORBEREITUNG, DIE S1-5 BEINHALTET
Title (fr)
PREPARATION PROTEINIQUE CONTENANT S1-5
Publication
Application
Priority
- JP 2005024137 W 20051228
- JP 2005012251 W 20050701
Abstract (en)
The present inventors discovered that knockout mice whose S1-5 gene function is lost develop age-related diseases or symptoms. In such knockout mice, bone mineral content, bone mineral density, and bone strength were found to be decreased, and the number of osteoclasts in bone tissues was found to be increased. Analysis of osteoclast-forming ability using bone marrow cells derived from the knockout mice revealed that osteoclast-forming ability is enhanced and osteoclasts are larger in the knockout mice than in wildtype mice. When purified S1-5 protein was added to this in vitro system, osteoclast-forming ability was inhibited. Furthermore, administration of purified S1-5 protein to osteoporotic model mice showed that this protein has the effect of improving osteoporosis. The above findings demonstrate that S1-5 protein is useful for treating and preventing age-related diseases such as osteoporosis.
IPC 8 full level
C12N 15/09 (2006.01); A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61P 19/10 (2006.01); A61P 43/00 (2006.01); C07K 14/435 (2006.01); C07K 16/18 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP KR US)
A01K 67/027 (2013.01 - EP US); A01K 67/0276 (2013.01 - EP US); A61P 5/18 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 7/10 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/14 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/47 (2013.01 - EP US); C12N 15/09 (2013.01 - KR); C12N 15/8509 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP US); A01K 2267/0368 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 2007004325A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
EP 1764413 A1 20070321; AU 2005333933 A1 20070111; CA 2613813 A1 20070111; CN 101258240 A 20080903; JP WO2007004325 A1 20090122; KR 20080032139 A 20080414; RU 2008103838 A 20090810; US 2010058488 A1 20100304; WO 2006004066 A1 20060112; WO 2007004325 A1 20070111
DOCDB simple family (application)
EP 05844884 A 20051228; AU 2005333933 A 20051228; CA 2613813 A 20051228; CN 200580051476 A 20051228; JP 2005012251 W 20050701; JP 2005024137 W 20051228; JP 2007523335 A 20051228; KR 20087002714 A 20080131; RU 2008103838 A 20051228; US 99432705 A 20051228