EP 1765162 A4 20081001 - CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
Title (en)
CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
Title (de)
KONTRASTMITTEL FÜR DIE MAGNETRESONANZTOMOGRAPHIE
Title (fr)
AGENTS DE CONTRASTES POUR L"IMAGERIE PAR RÉSONANCE MAGNÉTIQUE
Publication
Application
Priority
- US 2005017341 W 20050518
- US 57272604 P 20040518
Abstract (en)
[origin: WO2005112758A1] A contrast agent for magnetic resonance imaging having a plurality of nanoparticles (100, 200). Each of the nanoparticles (100, 200) has: a signal generating core (110, 210) having a diameter of up to 10 nm; at least one organic layer (120, 230) of at least one of a polymer, a monomer (122), and a surfactant; and a water soluble outer shell of at least one of a polymer, a monomer (122), and a ligand. The organic layer (120, 230) is adsorbed upon and substantially surrounds and stabilizes the signal generating core. The water soluble outer shell solubilizes and provides biocompatibility for each of the nanoparticles (100, 200). The contrast agents provide enhanced relaxivity, high signal-to-noise ratios, and targeting abilities. In addition, the contrast agents possess resistance to agglomeration, controlled particle size, blood clearance rate, and biodistribution. Methods of making such contrast agents and nanoparticles (100, 200) are also disclosed.
IPC 8 full level
A61B 5/055 (2006.01); A61K 47/48 (2006.01); A61K 49/18 (2006.01)
CPC (source: EP)
A61K 49/186 (2013.01); B82Y 5/00 (2013.01)
Citation (search report)
- [XY] US 2003185757 A1 20031002 - KRESSE MAYK [DE], et al
- [XDY] US 2004022937 A1 20040205 - BONITATEBUS PETER JOHN [US], et al
- [XY] US 5492814 A 19960220 - WEISSLEDER RALPH [US]
- [PX] LIU XIANQIAO ET AL: "Surface modification and characterization of magnetic polymer nanospheres prepared by miniemulsion polymerization", LANGMUIR, ACS, WASHINGTON, DC, US, vol. 20, no. 23, 6 October 2004 (2004-10-06), pages 10278 - 10282, XP002391024, ISSN: 0743-7463
- See references of WO 2005112758A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005112758 A1 20051201; EP 1765162 A1 20070328; EP 1765162 A4 20081001
DOCDB simple family (application)
US 2005017341 W 20050518; EP 05749298 A 20050518