EP 1767616 A3 20070613 - Method for producing L-amino acids or ketoacids employing coryneform bacteria with attenuated aceE (pdhA) expression
Title (en)
Method for producing L-amino acids or ketoacids employing coryneform bacteria with attenuated aceE (pdhA) expression
Title (de)
Verfahren zur Herstellung von L-Aminosäuren oder Ketosäuren unter Verwendung coryneformer Bakterien mit abgeschwächter aceE (pdhA) Expression
Title (fr)
Procédé de préparation de L-acides aminés ou de cétoacides en utilisant des bactéries coryneformes ayant une expression attenuée du gène aceE (pdhA)
Publication
Application
Priority
DE 102005045301 A 20050922
Abstract (en)
[origin: EP1767616A2] Preparation of an organic compound (I) by fermenting a coryneform bacterium (CB) in which the aceE gene, encoding the E1p sububit of the pyruvate dehydrogenase complex, has been weakened, in a suitable medium so that (I) is formed at increased level and accumulates in the cells and/or fermentation medium. Independent claims are included for the following: (1) CB in which the aceE gene has been weakened; and (2) recombinant CB in which the aceE gene has been switched off.
IPC 8 full level
C12N 1/21 (2006.01); C12P 7/42 (2006.01); C12P 13/06 (2006.01); C12P 13/08 (2006.01); C12P 13/12 (2006.01); C12P 13/20 (2006.01)
CPC (source: EP)
C12P 7/40 (2013.01); C12P 7/46 (2013.01); C12P 13/04 (2013.01); C12P 13/06 (2013.01); C12P 13/08 (2013.01); C12P 13/12 (2013.01); C12P 13/20 (2013.01)
Citation (search report)
- [XA] WO 03000913 A2 20030103 - FORSCHUNGSZENTRUM JUELICH GMBH [DE], et al
- [XA] WO 2005062923 A2 20050714 - MASSACHUSETTS INST TECHNOLOGY [US], et al
- [X] KALINOWSKI, J. ET AL.: "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins", JOURNAL OF BIOTECHNOLOGY, vol. 104, no. 1-3, 4 September 2003 (2003-09-04), pages 5 - 25, XP002371548
- [A] DATABASE EMBL [online] 1 October 2002 (2002-10-01), NAKAGAWA, S.: "Pyruvate dehydrogenase, decarboxylase component (EC 1.2.4.1) (PYRUVATE DEHYDROGENASE E1 COMPONENT)", XP002416366, Database accession no. Q8NNF6
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
EP 1767616 A2 20070328; EP 1767616 A3 20070613; DE 102005045301 A1 20070405
DOCDB simple family (application)
EP 06119615 A 20060828; DE 102005045301 A 20050922