Global Patent Index - EP 1773388 A4

EP 1773388 A4 20080820 - SARS VACCINES AND METHODS TO PRODUCE HIGHLY POTENT ANTIBODIES

Title (en)

SARS VACCINES AND METHODS TO PRODUCE HIGHLY POTENT ANTIBODIES

Title (de)

SARS-IMPFSTOFFE UND VERFAHREN ZUR HERSTELLUNG VON HOCHAKTIVEN ANTIKÖRPERN

Title (fr)

VACCINS CONTRE LE SRAS ET PROCEDES DE PRODUCTION D'ANTICORPS TRES PUISSANTS

Publication

EP 1773388 A4 20080820 (EN)

Application

EP 05786720 A 20050601

Priority

  • US 2005019266 W 20050601
  • US 57611804 P 20040602
  • US 14192505 A 20050531

Abstract (en)

[origin: WO2005120565A2] This invention provides a vaccine comprising an effective amount of an isolated polypeptide or recombinant protein containing the sequence of the receptor-binding domain in the SARS associated coronavirus spike protein or a functional fragment thereof, or a nucleic acid molecule comprising the sequence of a fragment which encodes the sequence of the receptor-binding domain in the Severe Acute Respiratory Syndrome associated coronavirus spike protein or a functional fragment thereof. This invention provides a composition for increasing the immunogenicity of an antigen comprising an effective amount of an antigen and an IgG Fc domain, its functional fragment, or a substance containing an IgG Fc domain or its functional fragment. The antigen and the IgG Fc may be linked or unlinked. Finally, this invention also provides method for using any of the above compositions for immunization.

IPC 8 full level

A61K 39/215 (2006.01); C07K 1/00 (2006.01); C07K 14/165 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP US)

C07K 14/005 (2013.01 - EP); A61K 39/00 (2013.01 - EP US); C07K 2319/30 (2013.01 - EP); C12N 2770/20022 (2013.01 - EP)

Citation (search report)

  • [X] YANG ZHI-YONG ET AL: "A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 428, no. 6982, 1 April 2004 (2004-04-01), pages 561 - 564, XP002304794, ISSN: 0028-0836
  • [Y] BISHT HIMANI ET AL: "Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 101, no. 17, 27 April 2004 (2004-04-27), pages 6641 - 6646, XP002391528, ISSN: 0027-8424
  • [Y] WONG SWEE KEE ET AL: "A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 279, no. 5, 30 January 2004 (2004-01-30), pages 3197 - 3201, XP002332535, ISSN: 0021-9258
  • [A] SUI JIANHUA ET AL: "Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 101, no. 8, 24 February 2004 (2004-02-24), pages 2536 - 2541, XP002332534, ISSN: 0027-8424
  • [A] BONAVIA A ET AL: "Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 77, no. 4, February 2003 (2003-02-01), pages 2530 - 2538, XP002342003, ISSN: 0022-538X
  • [A] LI WENHUI ET AL: "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 426, no. 6965, 27 November 2003 (2003-11-27), pages 450 - 454, XP002342002, ISSN: 0028-0836
  • [PX] HE Y ET AL: "Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 324, no. 2, 12 November 2004 (2004-11-12), pages 773 - 781, XP004599673, ISSN: 0006-291X

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005120565 A2 20051222; WO 2005120565 A3 20070518; WO 2005120565 A8 20060209; AU 2005251738 A1 20051222; CA 2569142 A1 20051222; EP 1773388 A2 20070418; EP 1773388 A4 20080820

DOCDB simple family (application)

US 2005019266 W 20050601; AU 2005251738 A 20050601; CA 2569142 A 20050601; EP 05786720 A 20050601