Global Patent Index - EP 1778206 A4

EP 1778206 A4 20090805 - SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF

Title (en)

SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF

Title (de)

KLEINMOLEKÜL-INHIBITOREN AUS ANGEHÖRIGEN DER ANTIOPTOTISCHEN BCL-2-FAMILIE UND VERWENDUNGEN DAMIT

Title (fr)

PETITS INHIBITEURS MOLECULAIRES DE MEMBRES DE LA FAMILLE DES ANTI-APOPTOSE BCL-2, ET UTILISATIONS CORRESPONDANTES

Publication

EP 1778206 A4 20090805 (EN)

Application

EP 05806407 A 20050822

Priority

  • US 2005029634 W 20050822
  • US 60341104 P 20040820

Abstract (en)

[origin: CN101039662A] The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.

IPC 8 full level

A61K 31/075 (2006.01); A61K 31/47 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); C07C 43/02 (2006.01); C07D 217/00 (2006.01); C07D 413/02 (2006.01)

CPC (source: EP)

C07C 43/02 (2013.01); C07D 217/00 (2013.01); C07D 413/02 (2013.01)

Citation (search report)

  • [X] US 2686123 A 19540810 - CAMPBELL TOD W, et al
  • [X] US 6114397 A 20000905 - FLACK MARY R [US], et al
  • [X] AMOLAK CHAND JAIN ET AL: "SYNTHESIS OF SOME NATURALLY OCCURRING ACETYLCHROMENES", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 52, no. 4, 1 January 1979 (1979-01-01), pages 1203/1204, XP001068520, ISSN: 0009-2673
  • [X] G. SCHILL, E. LOGEMANN: "4,6-Di-n-alkylpyrogallol-trimethyläther. Modellreaktionen zu gezielten Catenan-Synthesen", CHEMISCHE BERICHTE, vol. 106, 1973, pages 2910 - 2917, XP002533464
  • [X] M. C. SUTTER: "The pharmacology of isolated veins", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 24, no. 3, 1965, pages 742 - 751, XP009118730
  • See references of WO 2006023778A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

CN 101039662 A 20070919; EP 1778206 A2 20070502; EP 1778206 A4 20090805; MX 2007002104 A 20071010; ZA 200702257 B 20090624

DOCDB simple family (application)

CN 200580034757 A 20050822; EP 05806407 A 20050822; MX 2007002104 A 20050822; ZA 200702257 A 20050822