EP 1778841 A2 20070502 - GASTRIN-SPECIFIC INTERFERING RNA
Title (en)
GASTRIN-SPECIFIC INTERFERING RNA
Title (de)
GASTRIN-SPEZIFISCHE INTERFERIERENDE RNA
Title (fr)
ARN INTERFÉRANT SPÉCIFIQUE VIS-À-VIS DE LA GASTRINE
Publication
Application
Priority
- IB 2005002686 W 20050810
- US 60069604 P 20040811
Abstract (en)
[origin: WO2006016275A2] The invention provides gastrin-specific interfering ribonucleic acid (RNAi) molecules that down-regulate the gastrin hormone gene. The RNAi molecules of the invention are double-stranded RNA molecules that can include modified bases and non-phosphate linkages between the bases. The complementary strands of the RNAi molecules of the invention can be linked by a nucleotide chain or by non-nucleotide linkers. The RNAi molecules of the invention can be formulated in pharmaceutical compositions useful in a method for treating gastrin-mediated diseases or conditions including gastrin-mediated tumors, GERD, Zollinger-Ellison syndrome, hypergastrinemia, pernicious anemia, gastric ulceration, duodenal ulceration, and H. pylori infection.
IPC 8 full level
C12N 15/11 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP KR)
A61K 31/713 (2013.01 - KR); C07K 14/595 (2013.01 - KR); C12N 15/11 (2013.01 - KR); C12N 15/1136 (2013.01 - EP); C12N 2310/111 (2013.01 - EP); C12N 2310/14 (2013.01 - EP); C12N 2310/3517 (2013.01 - EP); C12N 2310/53 (2013.01 - EP)
Citation (search report)
See references of WO 2006016275A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006016275 A2 20060216; WO 2006016275 A3 20060518; AU 2005270917 A1 20060216; AU 2005270917 A8 20060216; CA 2576576 A1 20060216; EP 1778841 A2 20070502; KR 20070062515 A 20070615
DOCDB simple family (application)
IB 2005002686 W 20050810; AU 2005270917 A 20050810; CA 2576576 A 20050810; EP 05775595 A 20050810; KR 20077005675 A 20070309