Global Patent Index - EP 1779863 A1

EP 1779863 A1 20070502 - Use of TGF-Beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa

Title (en)

Use of TGF-Beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa

Title (de)

Verwendung von TGF-Beta und Wachstumfaktoren zur Behandlung und Vorbeugung von Krankheiten der Darmmucosa

Title (fr)

Utilisation de TGF-Beta et des facteurs de croissance pour le traitement et la prévention de maladies de la muqueuse intestinale

Publication

EP 1779863 A1 20070502 (EN)

Application

EP 07100978 A 20001006

Priority

  • NL 9900620 W 19991006
  • EP 00971890 A 20001006

Abstract (en)

The invention pertains to the use of transforming growth factor ² (TGF-²) in the preparation of a pharmaceutical or nutritional composition for use in the treatment and/or prevention of damage of the intestinal mucosa as a result of chemotherapy or radiotherapy, the pharmaceutical or nutritional composition comprising TGF-² and one or more binding factors for TGF-² in the substantial absence of insulin-like growth factor-1 (IGF-1) which TGF-² is obtainable by extraction from a mammalian milk whey product.

IPC 8 full level

A61K 38/18 (2006.01); A61K 47/16 (2006.01); A23L 1/30 (2006.01); A61K 33/06 (2006.01); A61K 35/20 (2006.01); A61K 36/00 (2006.01); A61K 36/899 (2006.01); A61K 38/00 (2006.01); A61K 38/30 (2006.01); A61K 38/40 (2006.01); A61K 39/395 (2006.01); A61K 47/36 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 1/12 (2006.01); A61K 31/20 (2006.01); A61K 31/715 (2006.01); A61K 38/05 (2006.01)

CPC (source: EP)

A61K 36/899 (2013.01); A61K 38/1841 (2013.01); A61K 38/30 (2013.01); A61K 38/40 (2013.01); A61P 1/00 (2017.12); A61P 1/04 (2017.12); A61P 1/12 (2017.12)

C-Set (source: EP)

  1. A61K 36/899 + A61K 2300/00
  2. A61K 38/1841 + A61K 2300/00
  3. A61K 38/30 + A61K 2300/00
  4. A61K 38/40 + A61K 2300/00

Citation (search report)

  • [XY] US 5824297 A 19981020 - IWATA KENNETH K [US], et al
  • [AD] EP 0756828 A1 19970205 - NUTRICIA NV [NL]
  • [A] EP 0269408 A2 19880601 - GENENTECH INC [US]
  • [DX] EP 0852913 A1 19980715 - NESTLE SA [CH]
  • [DX] EP 0462398 A1 19911227 - HOFFMANN LA ROCHE [CH]
  • [X] EP 0652015 A2 19950510 - BRISTOL MYERS SQUIBB CO [US], et al
  • [DY] WO 9634614 A1 19961107 - GROPEP PTY LTD [AU], et al
  • [DY] WO 9933355 A2 19990708 - NUTRICIA NV [NL], et al
  • [Y] WO 9203155 A1 19920305 - KABI PHARMACIA AB [SE]
  • [A] BECK P L & WALLACE J L: "Cytokines in inflammatory bowel disease.", MEDIATORS OF INFLAMMATION, vol. 6, no. 2, April 1997 (1997-04-01), pages 95 - 103, XP000929627
  • [A] BECK P L & PODOLSKY D K: "Growth factors in inflammatory bowel disease.", INFLAMMATORY BOWEL DISEASES, vol. 5, no. 1, 1 February 1999 (1999-02-01), pages 44 - 60, XP000929625
  • [A] PAKKANEN R ET AL: "Growth factors and antimicrobial factors of bovine colostrum.", INTERNATIONAL DAIRY JOURNAL, vol. 7, no. 5, 1997, pages 285 - 297, XP000929616
  • [A] BARNARD J A & WARWICK G: "Butyrate rapidly induces growth inhibition and differentaition in HT-29 cells", CELL GROWTH & DIFFERENTIATION, vol. 4, no. 6, June 1993 (1993-06-01), pages 495 - 501, XP000929383
  • [A] WADLEIGH R G ET AL.: "Vitamin E in the treatment of chemotherapy-induced mucositis", AMERICAN JOURNAL OF MEDICINE, vol. 92, May 1992 (1992-05-01), pages 481 - 484, XP000929488
  • [A] ANDERSON P A ET AL.: "Oral glutamine reduces the duration and severity of stomatitis after cancer chemotherapy", CANCER, vol. 83, no. 7, 1 October 1998 (1998-10-01), pages 1433 - 1439, XP000929455
  • [Y] HOWARTH G S ET AL.: "Insulin-like growth factor-1 partially attenuates colonic damage in rats with experimental colitis induced by oral dextran sulphate sodium", SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 33, no. 2, 1998, pages 180 - 190, XP000929385
  • [A] GUO Y-S ET AL.: "Differential regulation by TGF-beta1 and insulin of insulin-like growth factor binding protein-2 in IEC-6 cells", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 268, no. 6 (1/3), June 1995 (1995-06-01), pages E1199 - E1204, XP000929395
  • [PA] WALKER-SMITH J A: "Chronic inflammatory bowel disease in children: a complex problem in management", POSTGRADUATE MEDICAL JOURNAL, vol. 76, no. 898, August 2000 (2000-08-01), pages 469 - 472, XP000971805 & US 5817625 A 19981006 - HALEY JOHN DOUGLAS [US]

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0124812 A1 20010412; AU 1063201 A 20010510; AU 6232899 A 20010510; BR 0014563 A 20020611; CN 1299766 C 20070214; CN 1378458 A 20021106; CN 1626239 A 20050615; EP 1221965 A1 20020717; EP 1779863 A1 20070502; JP 2003510367 A 20030318; WO 0124813 A1 20010412

DOCDB simple family (application)

NL 9900620 W 19991006; AU 1063201 A 20001006; AU 6232899 A 19991006; BR 0014563 A 20001006; CN 00814004 A 20001006; CN 200410074961 A 20001006; EP 00971890 A 20001006; EP 07100978 A 20001006; JP 2001527812 A 20001006; NL 0000719 W 20001006