Global Patent Index - EP 1779865 A1

EP 1779865 A1 20070502 - Use of human growth hormone to stimulate mobilization of pluripotent hematopoietic stem cells

Title (en)

Use of human growth hormone to stimulate mobilization of pluripotent hematopoietic stem cells

Title (de)

Verwendung von menschlichem Wachstumshormon zur Stimulierung der Mobilisierung pluripotenter hematopoietischer Stammzellen

Title (fr)

Utilisation de l'hormone de croissance humaine pour stimuler la mobilisation de cellules souches hématopoïetiques pluripotentes

Publication

EP 1779865 A1 20070502 (EN)

Application

EP 06021178 A 19991230

Priority

  • EP 99965579 A 19991230
  • EP 98124834 A 19981230
  • EP 06021178 A 19991230

Abstract (en)

The invention relates to the field of hematopoietic CD34 + cell mobilization. In particular, this invention relates to a method for increasing the mobilization of pluripotent hematopoietic CD34 + cells by administration of human growth hormone or one of its derivates to the individual.

IPC 8 full level

A61K 38/27 (2006.01); A61K 35/14 (2006.01); A61K 35/28 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 39/395 (2006.01); A61P 7/00 (2006.01); A61P 7/06 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/00 (2006.01); C12N 5/06 (2006.01); C12N 5/08 (2006.01); A61K 35/00 (2006.01); A61K 38/19 (2006.01)

CPC (source: EP US)

A61K 38/27 (2013.01 - EP US); A61P 7/00 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61K 35/00 (2013.01 - EP US)

Citation (applicant)

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  • GIANNI, A.M. ET AL.: "Rapid and complete hemopoietic reconstitution following combined transplantation of autologous blood and bone marrow cells. A changing role for high dose chemo-radiotherapy", HEMATOL.ONCOL., vol. 7, 1989, pages 139 - 148
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  • JORGENSEN, J. O. ET AL.: "Serum profiles and short-term metabolic effect of pituitary and authentic biosynthetic human growth hormone in man. A double-blind cross-over study", ACTA ENDOCRINOL.(COPENH., vol. 116, 1987, pages 381 - 386
  • JORGENSEN, K.D. ET AL.: "Pharmacokinetics of biosynthetic and pituitary human growth hormones in rats", PHARMACOL.TOXICOL., vol. 63, 1988, pages 129 - 134
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  • LARSSON, K.; BJORKSTRAND, B.; LJUNGMAN, P.: "Faster engraftment but no reduction in infectious complications after peripheral blood stem cell transplantation compared to autologous bone marrow transplantation", SUPPORT.CARE CANCER, vol. 6, 1998, pages 378 - 383
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Citation (search report)

  • [A] US 5199942 A 19930406 - GILLIS STEVEN [US]
  • [A] WO 9428916 A1 19941222 - BRITISH BIOTECH PHARM [GB], et al
  • [A] US 5649904 A 19970722 - GIANNI ALESSANDRO M [IT]
  • [E] WO 0030675 A2 20000602 - A & SCIENCE INVEST AB [SE], et al
  • [E] EP 1016414 A2 20000705 - APPLIED RESEARCH SYSTEMS [AN]
  • [Y] PATENT ABSTRACTS OF JAPAN vol. 095, no. 007 31 August 1995 (1995-08-31)
  • [Y] TIAN Z G ET AL: "Recombinant human growth hormone promotes hematopoietic reconstitution after syngeneic bone marrow transplantation in mice.", STEM CELLS, (1998) 16 (3) 193-9., 1998, XP002114334
  • [Y] BREGNI M ET AL: "Comparative effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony - stimulating factor after high-dose cyclophosphamide cancer therapy.", JOURNAL OF CLINICAL ONCOLOGY, (1996 FEB) 14 (2) 628-35., 1996, XP000877223
  • [Y] MURPHY W J ET AL: "GROWTH HORMONE EXERTS HEMATOPOIETIC GROWTH-PROMOTING EFFECTS IN VIVO AND PARTIALLY COUNTERACTS THE MYELOSUPPRESSIVE EFFECTS OF AZIDOTHYMIDINE", BLOOD, vol. 80, no. 6, 15 September 1992 (1992-09-15), pages 1443 - 1447, XP002065327
  • [Y] MIYASHITA Y: "The effect of growth hormone on leukopoiesis: in vivo and in vitro studies.", NIPPON NAIBUNPI GAKKAI ZASSHI. FOLIA ENDOCRINOLOGICA JAPONICA, (1991 JUL 20) 67 (7) 785-95., 1991, XP002114569
  • [Y] MURPHY W J ET AL: "Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1992 MAY 15) 89 (10) 4481-5., 1992, XP002114570
  • [A] KÖRBLING M ET AL: "Allogeneic peripheral blood stem cell transplantation using normal patient-related pediatric donors", BONE MARROW TRANSPLANTATION, vol. 18, no. 5, November 1996 (1996-11-01), pages 885 - 890, XP002114335
  • [A] OHMIZONO Y ET AL: "THROMBOPOIETIN AUGMENTS EX VIVO EXPANSION OF HUMAN CORD BLOOD -DERIVED HEMATOPOIETIC PROGENITORS IN COMBINATION WITH STEM CELL FACTOR AND FLT3 LIGAND", LEUKEMIA, vol. 11, no. 4, 1 April 1997 (1997-04-01), pages 524 - 530, XP002053902

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

AL LT LV MK RO SI

DOCDB simple family (publication)

EP 1016413 A1 20000705; AT E342064 T1 20061115; AU 2004203355 A1 20040819; AU 2004203355 B2 20070517; AU 2103900 A 20000724; AU 772222 B2 20040422; BR 9916726 A 20010911; CA 2354194 A1 20000713; CY 1107603 T1 20130313; DE 69933581 D1 20061123; DE 69933581 T2 20070621; DK 1140149 T3 20070219; EP 1140149 A1 20011010; EP 1140149 B1 20061011; EP 1779865 A1 20070502; ES 2275359 T3 20070601; IL 143994 A0 20020421; IL 143994 A 20090615; JP 2002534393 A 20021015; JP 4808316 B2 20111102; PT 1140149 E 20070131; SI 1140149 T1 20070228; US 2006029581 A1 20060209; WO 0040260 A1 20000713

DOCDB simple family (application)

EP 98124834 A 19981230; AT 99965579 T 19991230; AU 2004203355 A 20040722; AU 2103900 A 19991230; BR 9916726 A 19991230; CA 2354194 A 19991230; CY 071100021 T 20070108; DE 69933581 T 19991230; DK 99965579 T 19991230; EP 06021178 A 19991230; EP 9910470 W 19991230; EP 99965579 A 19991230; ES 99965579 T 19991230; IL 14399401 A 20010626; IL 14399499 A 19991230; JP 2000592015 A 19991230; PT 99965579 T 19991230; SI 9930937 T 19991230; US 23787605 A 20050929