EP 1781823 A2 20070509 - IN VIVO ASSAYS FOR MODULATION OF SMAD-MEDIATED SIGNALING
Title (en)
IN VIVO ASSAYS FOR MODULATION OF SMAD-MEDIATED SIGNALING
Title (de)
IN-VIVO-PRÜFUNGEN ZUR MODULATION VON SMAD-VERMITTELTER SIGNALISIERUNG
Title (fr)
DOSAGES IN VIVO POUR MODULATION DE SIGNALISATION A MEDIATION SMAD
Publication
Application
Priority
- US 2005025056 W 20050714
- US 58834304 P 20040716
Abstract (en)
[origin: WO2006019954A2] The disclosure provides an assay system for evaluating compounds that modulate Smad3-mediated gene regulation, and the TGF-ß/activin signaling pathway, in particular. The methods utilize a reporter construct responsive in vivo to a member of the TGF-ß superfamily (e.g., TGF-ß or activin). The reporter construct includes a tandem of <i
IPC 8 full level
C12Q 1/68 (2006.01); A01K 67/027 (2006.01); C12N 15/63 (2006.01)
CPC (source: EP)
C12Q 1/6897 (2013.01)
Citation (search report)
See references of WO 2006019954A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006019954 A2 20060223; WO 2006019954 A3 20060518; EP 1781823 A2 20070509
DOCDB simple family (application)
US 2005025056 W 20050714; EP 05791000 A 20050714