EP 1783230 B1 20081210 - Feedback-resistent homoserin-transsuccinylases
Title (en)
Feedback-resistent homoserin-transsuccinylases
Title (de)
Feedback-resistente Homoserin-Transsuccinylasen
Title (fr)
Homosérine transsuccinylases resistantes à la rétroaction
Publication
Application
Priority
- EP 03767502 A 20031002
- DE 10247437 A 20021011
Abstract (en)
[origin: WO2004035617A2] The invention concerns a homoserin transuccinylase having at least one mutation compared to a wild-type homoserine transsuccinylase and reduced sensitivity towards to L-methionine or SAM, compared to the wild-type enzyme. The latter comprises an amino acid sequence including a partial AspGlyXaaXaaXaaThrGlyAlaPro sequence between position 90 and position 115 and a partial TyrGlnXaaThrPro sequence between position 285 and position 310, position 1 of the amino acid sequence corresponding to the initial methionine. The invention is characterized in that the mutation is a substitution of the aspartate in the partial AspGlyXaa-XaaXaaThrGlyAlaPro sequence, or a substitution of the tyrosine in the partial TyrGlnXaaThrPro sequence.
IPC 8 full level
C12P 13/12 (2006.01); C12N 9/10 (2006.01); C12N 15/09 (2006.01); C12P 19/40 (2006.01)
CPC (source: EP US)
C12N 9/1029 (2013.01 - EP US); C12P 13/12 (2013.01 - EP US); C12P 19/40 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004035617 A2 20040429; WO 2004035617 A3 20040617; AT E371744 T1 20070915; AT E417120 T1 20081215; CN 1324131 C 20070704; CN 1703517 A 20051130; DE 10247437 A1 20040429; DE 50308082 D1 20071011; DE 50310917 D1 20090122; EP 1549754 A2 20050706; EP 1549754 B1 20070829; EP 1783230 A2 20070509; EP 1783230 A3 20070808; EP 1783230 B1 20081210; ES 2290504 T3 20080216; ES 2317612 T3 20090416; JP 2006516092 A 20060622; US 7371551 B1 20080513
DOCDB simple family (application)
EP 0310978 W 20031002; AT 03767502 T 20031002; AT 07102437 T 20031002; CN 200380101208 A 20031002; DE 10247437 A 20021011; DE 50308082 T 20031002; DE 50310917 T 20031002; EP 03767502 A 20031002; EP 07102437 A 20031002; ES 03767502 T 20031002; ES 07102437 T 20031002; JP 2004544072 A 20031002; US 53084303 A 20031002