EP 1786412 A1 20070523 - ARENE RUTHENIUM (II) COMPOUNDS AND THEIR USE IN CANCER THERAPY
Title (en)
ARENE RUTHENIUM (II) COMPOUNDS AND THEIR USE IN CANCER THERAPY
Title (de)
AREN-RUTHENIUM (II)-VERBINDUNGEN UND IHRE VERWENDUNG IN DER KREBSTHERAPIE
Title (fr)
COMPOSES ARENE-RUTHENIUM (II) ET LEUR UTILISATION DANS LA THERAPIE DU CANCER.
Publication
Application
Priority
- GB 2005003242 W 20050819
- GB 0418643 A 20040820
Abstract (en)
[origin: WO2006018649A1] A ruthenium (II) compound of formula (I): or a solvate or prodrug thereof, wherein: R<SUP>1</SUP>, R<SUP>1</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP> and R<SUP>6</SUP> are independently selected from H, C<SUB>1-7</SUB> alkyl, C<SUB>5-20</SUB> aryl, C<SUB>3-20</SUB> heterocyclyl, halo, ester, amido, acyl, sulfo, sulfonamido, ether, thioether, azo, amino, or R<SUP>1</SUP> and R<SUP>2</SUP> together with the ring to which they are attached form a saturated or unsaturated carbocyclic or heterocyclic group containing up to three 3- to 8- membered carbocyclic or heterocyclic rings, wherein each carbocyclic or heterocyclic ring may be fused to one or more other carbocyclic or heterocyclic rings; X is a neutral or negatively charged N- or S- donor ligand; Y is a counterion; m is 0 or 1; q is 1, 2 or 3; C' is C<SUB>1-12</SUB> alkylene bound to two A groups; p is 0 or 1 and r is 1 when p is 0 and r is 2 when p is 1; and A and B are each independently O-donor, N-donor or S-donor ligands, and may be connected to one another. The compounds are used in cancer therapy.
IPC 8 full level
A61K 31/28 (2006.01); A61P 35/00 (2006.01); C07F 15/00 (2006.01)
CPC (source: EP KR)
A61K 31/28 (2013.01 - KR); A61P 35/00 (2017.12 - EP); C07F 15/00 (2013.01 - KR); C07F 15/0046 (2013.01 - EP)
Citation (search report)
See references of WO 2006018649A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006018649 A1 20060223; AU 2005273726 A1 20060223; BR PI0514430 A 20080506; CA 2578280 A1 20060223; CN 101043885 A 20070926; EP 1786412 A1 20070523; GB 0418643 D0 20040922; JP 2008510693 A 20080410; KR 20070060091 A 20070612; MX 2007002099 A 20070424; NO 20071481 L 20070516; ZA 200702093 B 20080827
DOCDB simple family (application)
GB 2005003242 W 20050819; AU 2005273726 A 20050819; BR PI0514430 A 20050819; CA 2578280 A 20050819; CN 200580035541 A 20050819; EP 05771813 A 20050819; GB 0418643 A 20040820; JP 2007526570 A 20050819; KR 20077006364 A 20070320; MX 2007002099 A 20050819; NO 20071481 A 20070320; ZA 200702093 A 20070312