EP 1787660 A1 20070523 - New adjuvants on the basis of bisacyloxypropylcysteine conjugates and their uses in pharmaceutical compositions
Title (en)
New adjuvants on the basis of bisacyloxypropylcysteine conjugates and their uses in pharmaceutical compositions
Title (de)
Neue Adjuvanten auf der Basis von Bisacyloxypropylcystein-Konjugaten und ihre Verwendungen in pharmazeuthischen Zusammensetzungen.
Title (fr)
Nouveaux adjuvants a base des conjugés de bisacyloxypropylcystéine et leurs utilisations en compositions pharmaceutiques
Publication
Application
Priority
EP 05025431 A 20051122
Abstract (en)
The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EP KR US)
A61K 47/60 (2017.07 - EP US); A61P 15/00 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); C07C 321/14 (2013.01 - KR); C07C 323/11 (2013.01 - KR); C07C 323/25 (2013.01 - KR)
Citation (applicant)
- WO 2004009125 A2 20040129 - BIOTECHNOLOG FORSCHUNG GMBH [DE], et al
- WO 03084568 A2 20031016 - BIOTECHNOLOG FORSCHUNG GMBH [DE], et al
- WO 2004108634 A2 20041216 - CELARES GMBH [DE], et al
- MCGHEE, J.R. ET AL.: "The mucosal immune system: from fundamental concepts to vaccine development", VACCINE, vol. 10, 1992, pages 75 - 88
- "LEXIKON DER BIOCHEMIE UND MOLEKULARBIOLOGIE", vol. 1, 1995, AKADEMISCHER VERLAG
- VAJDY, IMMUNOL. CELL BIOL., vol. 82, 2004, pages 617 - 627
- VERONESE F.M., BIOMATERIALS, vol. 22, 2001, pages 405 - 417
- KODERA Y., PROG. POLYM. SCI., vol. 23, 1998, pages 1233 - 1271
- REMINGTON'S: "PHARMACEUTICAL SCIENCES", 1990, MACK PUBLISHING CO.
- BERKS, TIBTECH, vol. 12, 1994, pages 352 - 364
Citation (search report)
- [DY] WO 2004009125 A2 20040129 - BIOTECHNOLOG FORSCHUNG GMBH [DE], et al
- [DY] WO 2004108634 A2 20041216 - CELARES GMBH [DE], et al
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
EP 1787660 A1 20070523; AU 2006316791 A1 20070531; AU 2006316791 B2 20120712; BR PI0618847 A2 20111004; CA 2628736 A1 20070531; CN 101360514 A 20090204; EA 200801411 A1 20081030; EP 1973571 A1 20081001; JP 2009517350 A 20090430; JP 5249041 B2 20130731; KR 20080069267 A 20080725; US 2009017106 A1 20090115; US 8119689 B2 20120221; WO 2007059931 A1 20070531; WO 2007059931 A8 20070719; ZA 200804163 B 20091028
DOCDB simple family (application)
EP 05025431 A 20051122; AU 2006316791 A 20061122; BR PI0618847 A 20061122; CA 2628736 A 20061122; CN 200680051567 A 20061122; EA 200801411 A 20061122; EP 06818729 A 20061122; EP 2006011182 W 20061122; JP 2008541631 A 20061122; KR 20087015145 A 20080620; US 9386506 A 20061122; ZA 200804163 A 20061122