EP 1789385 A1 20070530 - METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES
Title (en)
METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINEN
Title (fr)
PROCEDE DE FABRICATION DE N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES
Publication
Application
Priority
- EP 2005002047 W 20050226
- EP 04005272 A 20040305
- DE 102004032828 A 20040706
- EP 05707642 A 20050226
Abstract (en)
[origin: US2005197503A1] The present invention relates to an improved process for preparing chiral N-substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine on an industrial scale using an asymmetric hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.
IPC 8 full level
C07D 201/00 (2006.01); C07D 333/16 (2006.01); C07D 333/20 (2006.01)
CPC (source: EP US)
C07D 333/16 (2013.01 - EP US)
Citation (search report)
See references of WO 2005085192A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2005197503 A1 20050908; CA 2556994 A1 20050915; EP 1789385 A1 20070530; JP 2007525532 A 20070906; WO 2005085192 A1 20050915
DOCDB simple family (application)
US 6051005 A 20050216; CA 2556994 A 20050226; EP 05707642 A 20050226; EP 2005002047 W 20050226; JP 2007501186 A 20050226