EP 1793843 A1 20070613 - MACROCYCLIC SH2 DOMAIN BINDING INHIBITORS
Title (en)
MACROCYCLIC SH2 DOMAIN BINDING INHIBITORS
Title (de)
MAKROZYKLISCHE SH2-DOMÄNE BINDENDE INHIBITOREN
Title (fr)
INHIBITEURS DE LIAISON DE DOMAINE SH2 MACROCYCLIQUE
Publication
Application
Priority
- US 2005035246 W 20050930
- US 61480004 P 20040930
Abstract (en)
[origin: WO2006039527A1] Disclosed are compounds for inhibiting the binding of an SH2 domain-containing protein, for example, a compound of formula (I): FORMULA (I) wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is, for example, hydrogen, azido, amino, oxalylamino, carboxy alkyl, alkoxycarbonyl alkyl, aminocarbonyl alkyl, or alkyl carbonylamino; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a pharmaceutically acceptable salt, stereoisomer, solvate, or hydrate thereof. Also disclosed are pharmaceutical compositions and methods of use of such compounds.
IPC 8 full level
A61K 38/12 (2006.01); A61K 31/675 (2006.01); A61P 35/00 (2006.01); C07F 9/553 (2006.01); C07K 5/12 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07F 9/5532 (2013.01); C07K 5/06191 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 2006039527A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006039527 A1 20060413; AU 2005291957 A1 20060413; CA 2582908 A1 20060413; EP 1793843 A1 20070613
DOCDB simple family (application)
US 2005035246 W 20050930; AU 2005291957 A 20050930; CA 2582908 A 20050930; EP 05805719 A 20050930