EP 1799843 A4 20080409 - ASSAY FOR CYTOCHROME P450 ISOFORM 2C9
Title (en)
ASSAY FOR CYTOCHROME P450 ISOFORM 2C9
Title (de)
ASSAY FÜR CYTOCHROM-P450-ISOFORM-2C9
Title (fr)
ESSAI POUR CYTOCHROME P450 ISOFORME 2C9
Publication
Application
Priority
- US 2005035688 W 20051004
- US 61694304 P 20041007
Abstract (en)
[origin: WO2006041844A2] A Rapid And Sensitive Radiometric Assay For Assessing The Activity Of Cytochrome P-450 (CYP) 2C9 And The Potential Of An Analyte To Inhibit CYP2C9 Activity Or Induce CYP2C9 Expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated.
IPC 8 full level
C12Q 1/26 (2006.01); G01N 33/567 (2006.01); G01N 33/86 (2006.01)
CPC (source: EP US)
C12Q 1/26 (2013.01 - EP US); G01N 2333/90245 (2013.01 - EP US); G01N 2500/02 (2013.01 - EP US)
Citation (search report)
- [PX] DI MARCO ANNALISE ET AL: "Development and validation of a high-throughput radiometric CYP2C9 inhibition assay using tritiated diclofenac", DRUG METABOLISM AND DISPOSITION, vol. 33, no. 3, March 2005 (2005-03-01), pages 359 - 364, XP002470064, ISSN: 0090-9556
- [A] LEIS H J ET AL: "Preparation of deuterated diclofenac for use as an internal standard in quantitative measurement by gas chromatography negative-ion chemical ionization mass spectrometry", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 10, no. 13, 1996, pages 1605 - 1606, XP002470065, ISSN: 0951-4198
- [Y] WADIA M S ET AL: "A CONVENIENT PREPARATION OF N-ALKYL AND N-ARYLAMINES BY SMILES REARRANGEMENT-SYNTHESIS OF ANALOGUES OF DICLOFENAC", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS, PHILADELPHIA, PA, US, vol. 33, no. 15, 2003, pages 2725 - 2736, XP001194841, ISSN: 0039-7911
- [Y] MOSER P ET AL: "SYNTHESIS AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF DICLOFENAC ANALOGUES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, 1990, pages 2358 - 2368, XP001024801, ISSN: 0022-2623
- See references of WO 2006041844A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006041844 A2 20060420; WO 2006041844 A3 20060803; CA 2582627 A1 20060420; EP 1799843 A2 20070627; EP 1799843 A4 20080409; JP 2008515426 A 20080515; US 2008193950 A1 20080814; US 7629140 B2 20091208
DOCDB simple family (application)
US 2005035688 W 20051004; CA 2582627 A 20051004; EP 05810880 A 20051004; JP 2007535754 A 20051004; US 66358705 A 20051004