EP 1802560 A4 20100331 - HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF
Title (en)
HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF
Title (de)
HALOCOMB-STATINE UND VERFAHREN ZU IHRER HERSTELLUNG
Title (fr)
HALOCOMBSTATINES ET LEURS METHODES DE SYNTHESE
Publication
Application
Priority
- US 2005033998 W 20050923
- US 94892604 A 20040924
- US 61288804 P 20040924
Abstract (en)
[origin: WO2006036743A2] The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.
IPC 8 full level
C07C 39/21 (2006.01); A61K 31/05 (2006.01); A61K 31/405 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); C07D 413/02 (2006.01); C07F 9/59 (2006.01); C07F 9/6533 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07C 43/23 (2013.01); C07F 9/12 (2013.01)
Citation (search report)
- [XP] MUGABE, TRAWICK, MONK, SILES, MALLINATH, GARNER, KANE, PINNEY: "Biological evaluation of mono and dichloro-substituted combretastatin analogs as inhibitors of tubulin polymerization", FASEB JOURNAL, vol. 19, 4 March 2005 (2005-03-04), pages A276 - A277, XP009122799
- See references of WO 2006036743A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006036743 A2 20060406; WO 2006036743 A3 20060526; AU 2005289773 A1 20060406; CA 2582046 A1 20060406; EP 1802560 A2 20070704; EP 1802560 A4 20100331; JP 2008514614 A 20080508
DOCDB simple family (application)
US 2005033998 W 20050923; AU 2005289773 A 20050923; CA 2582046 A 20050923; EP 05816139 A 20050923; JP 2007533629 A 20050923