EP 1804787 A2 20070711 - FLAVONOID COMPOSITION FOR TREATING ORAL DISEASES
Title (en)
FLAVONOID COMPOSITION FOR TREATING ORAL DISEASES
Title (de)
FLAVONOIDZUSAMMENSETZUNG ZUR BEHANDLUNG ORALER ERKRANKUNGEN
Title (fr)
COMPOSITION FLAVONOIDE POUR LE TRAITEMENT DES MALADIES BUCCO-DENTAIRES
Publication
Application
Priority
- US 2005037936 W 20051019
- US 62016304 P 20041019
Abstract (en)
[origin: WO2006045056A2] The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).
IPC 8 full level
A61K 31/35 (2006.01); A61K 8/49 (2006.01); A61K 8/97 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/68 (2006.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); A61K 36/11 (2006.01); A61K 36/15 (2006.01); A61K 36/185 (2006.01); A61K 36/28 (2006.01); A61K 36/47 (2006.01); A61K 36/48 (2006.01); A61K 36/484 (2006.01); A61K 36/486 (2006.01); A61K 36/53 (2006.01); A61K 36/539 (2006.01); A61K 36/54 (2006.01); A61K 36/60 (2006.01); A61K 36/906 (2006.01); A61K 36/9062 (2006.01); A61K 45/06 (2006.01); A61K 47/00 (2006.01); A61P 1/02 (2006.01); A61Q 11/00 (2006.01)
CPC (source: EP KR)
A61K 8/498 (2013.01 - EP); A61K 8/602 (2013.01 - EP); A61K 9/14 (2013.01 - KR); A61K 31/352 (2013.01 - EP); A61K 31/353 (2013.01 - EP KR); A61K 31/553 (2013.01 - EP); A61K 31/7048 (2013.01 - EP); A61K 36/11 (2013.01 - EP); A61K 36/15 (2013.01 - EP); A61K 36/185 (2013.01 - EP); A61K 36/28 (2013.01 - EP); A61K 36/47 (2013.01 - EP); A61K 36/48 (2013.01 - EP); A61K 36/484 (2013.01 - EP); A61K 36/486 (2013.01 - EP); A61K 36/53 (2013.01 - EP); A61K 36/539 (2013.01 - EP); A61K 36/54 (2013.01 - EP); A61K 36/60 (2013.01 - EP); A61K 36/906 (2013.01 - EP); A61K 36/9062 (2013.01 - EP); A61K 45/06 (2013.01 - EP); A61P 1/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); A61Q 11/00 (2013.01 - EP); A61K 2800/782 (2013.01 - EP); Y02A 50/30 (2017.12 - EP)
Citation (third parties)
Third party :
- DATABASE TKDL [online] "Zimaad Baraae Qooba", XP003028037, Database accession no. AH3/876C & ALI LBN-E- ABBAAS MAJOOSI: "Kaamil-al- Sena'ah", 2005, pages: 129
- DATABASE TKDL [online] "Manjan Deegar", XP003028038, Database accession no. NA4/4357 & MOHAMMAD NAJMUL GHANI KHAN: "Qaraabaadeen Najm-al-Ghani", 1928, pages: 667
- DATABASE TKDL [online] "Dantakurcika(04)", XP003028039, Database accession no. RS/3007D & BHAVAMISRA: "Bhavaprakasa", 1999, pages: 110
- DATABASE TKDL [online] "Gandusadharanadigunaah", XP003028040, Database accession no. AT/2103 & VAGBHATA: "Astanga Samgraha", 1991, pages: 27
- DATABASE TKDL [online] "Dantasula Cikitsa", XP003028041, Database accession no. RG2/525 & SODHALA: "Gadanigrahah", 1999, pages: 225
- DATABASE TKDL [online] "Sanoon Bara-e-Zirs", XP003028042, Database accession no. AH5/610 & MOHAMMAD AKMAL KHAN: "Qaraabaadeen Azam wa Akmal", 1909, pages: 410
- DATABASE TKDL [online] "Nuskha Sanoon", XP003028043, Database accession no. BA3/1032 & MOHAMMAD AKMAL KHAN: "Qaraabaadeen Azam wa Akmal", 1909, pages: 173
- DATABASE TKDL [online] "Khadiradyam Tailam", XP003028044, Database accession no. AK2/158 & SODHALA: "Gadanigrahah", 1999, pages: 107 - 108
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK YU
DOCDB simple family (publication)
WO 2006045056 A2 20060427; WO 2006045056 A3 20070201; AU 2005295190 A1 20060427; BR PI0518218 A 20081104; CA 2584124 A1 20060427; CN 101083981 A 20071205; CN 101083981 B 20130327; EP 1804787 A2 20070711; EP 1804787 A4 20090114; JP 2008517069 A 20080522; KR 20070073921 A 20070710; MX 2007004471 A 20070618; NZ 554517 A 20110225; RU 2007118535 A 20081127; TW 200630102 A 20060901
DOCDB simple family (application)
US 2005037936 W 20051019; AU 2005295190 A 20051019; BR PI0518218 A 20051019; CA 2584124 A 20051019; CN 200580043644 A 20051019; EP 05810437 A 20051019; JP 2007538073 A 20051019; KR 20077011409 A 20070518; MX 2007004471 A 20051019; NZ 55451705 A 20051019; RU 2007118535 A 20051019; TW 94136336 A 20051018