EP 1805313 A1 20070711 - METHOD FOR PRODUCING CHIRAL ALCOHOLS
Title (en)
METHOD FOR PRODUCING CHIRAL ALCOHOLS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON CHIRALEN ALKOHOLEN
Title (fr)
PRODUCTION D'ALCOOLS CHIRAUX
Publication
Application
Priority
- EP 2005011459 W 20051026
- AT 18082004 A 20041027
Abstract (en)
[origin: WO2006045598A1] The invention relates to a method for producing an enantiopure alcohol of general formula (Ia) or (Ib), wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R.<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB> and R<SUB>6</SUB> each represent hydrogen, halogen, a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl or C<SUB>1</SUB>-C<SUB>6</SUB> alkoxy group, with the proviso that at least one of the groups R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB> and R<SUB>6</SUB> is different from the remaining five groups and with the additional proviso that at least one of the groups R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB> and R<SUB>6</SUB> is a halogen. The invention is characterized in that a ketone of general formula (II), wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB> and R<SUB>6</SUB> are defined as above, is enzymatically reduced in the presence of an S-specific or R-specific dehydrogenase/oxidoreductase using NADH or NADPH as the cofactor.
IPC 8 full level
C12P 7/04 (2006.01); C07C 31/34 (2006.01); C07C 233/05 (2006.01); C12P 7/16 (2006.01); C12P 13/02 (2006.01)
CPC (source: EP KR US)
C12P 7/04 (2013.01 - EP KR US); C12P 7/06 (2013.01 - KR); C12P 7/16 (2013.01 - EP US); C12P 13/02 (2013.01 - EP US); C12P 41/00 (2013.01 - KR); Y02E 50/10 (2013.01 - EP US)
Citation (search report)
See references of WO 2006045598A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006045598 A1 20060504; AT 501928 A1 20061215; AT 501928 B1 20100915; CA 2585411 A1 20060504; CN 101120094 A 20080206; CN 101120094 B 20120808; EP 1805313 A1 20070711; JP 2008517612 A 20080529; KR 20070085458 A 20070827; US 2009148917 A1 20090611
DOCDB simple family (application)
EP 2005011459 W 20051026; AT 18082004 A 20041027; CA 2585411 A 20051026; CN 200580044779 A 20051026; EP 05800828 A 20051026; JP 2007538326 A 20051026; KR 20077011888 A 20070525; US 71811805 A 20051026