EP 1807067 A4 20100818 - SPHINGOSINE KINASE ACTIVATOR AND SKIN DISEASE TREATING AGENT COMPRISING THE SAME
Title (en)
SPHINGOSINE KINASE ACTIVATOR AND SKIN DISEASE TREATING AGENT COMPRISING THE SAME
Title (de)
SPHINGOSINKINASE-AKTIVATOR UND BEHANDLUNGSMITTEL FÜR HAUTKRANKHEITEN DAMIT
Title (fr)
ACTIVATEUR DE LA SPHINGOSINE KINASE ET AGENT DE TRAITEMENT DE MALADIES CUTANEES COMPRENANT CELUI-CI
Publication
Application
Priority
- KR 2005003586 W 20051027
- KR 20040088553 A 20041103
- KR 20050096591 A 20051013
Abstract (en)
[origin: WO2006049404A1] Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids. Therefore, the sphingosine kinase activator is useful for a skin disease treating agent for treating skin wounds, wrinkles, atopic dermatitis, eczema, psoriasis, or skin atrophy caused by side effects of local application steroids.
IPC 8 full level
A61K 8/68 (2006.01); A61K 31/164 (2006.01); A61Q 19/00 (2006.01)
CPC (source: EP)
A61K 8/68 (2013.01); A61Q 19/08 (2013.01); C07C 235/08 (2013.01); C07C 235/74 (2013.01)
Citation (search report)
- [A] CASTIEL-HIGOUNENC I ET AL: "AUGMENTATION DU CONTENU EN CERAMIDES DES EPIDERMES HUMAINS RECONSTRUITS APRES TRAITEMENT AVEC UN SPHINGOLIPIDE EXOGENE A BASE SPHINGANINE//EXOGENOUS SPHINGANIN DERIVED SPHINGOLIPID INCREASES EPIDERMAL CERAMIDE CONTENT IN HUMAN RECONSTRUCTED SKIN", NOUVELLES DERMATOLOGIQUES, STRASBOURG, FR, vol. 18, no. 8, 1 January 1999 (1999-01-01), pages 541 - 546, XP008022965, ISSN: 0752-5370
- See references of WO 2006049404A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006049404 A1 20060511; EP 1807067 A1 20070718; EP 1807067 A4 20100818
DOCDB simple family (application)
KR 2005003586 W 20051027; EP 05817632 A 20051027